C19orf52 Activators
C19orf52 can engage distinct signaling pathways to modulate its activity. Forskolin, by directly stimulating adenylyl cyclase, raises the intracellular levels of cAMP, which subsequently activates protein kinase A (PKA). Once activated, PKA can phosphorylate various proteins, including C19orf52, assuming it is a substrate for PKA. Similarly, Isoproterenol and Epinephrine operate through the beta-adrenergic receptors to elevate cAMP levels and activate PKA, leading to the phosphorylation of C19orf52. Another cAMP analog, Dibutyryl-cAMP, permeates cell membranes to directly activate PKA, and by extension, can phosphorylate C19orf52. Additionally, 8-Br-cAMP, a cAMP analog, activates PKA, which may then target C19orf52 for phosphorylation.
PMA stimulates protein kinase C (PKC), which phosphorylates a range of proteins, potentially including C19orf52 if it is within PKC's array of substrates. Ionomycin acts as a calcium ionophore, increasing intracellular calcium levels and activating calcium-dependent kinases that could phosphorylate C19orf52. A23187, another calcium ionophore, similarly increases intracellular calcium, which might activate C19orf52 through calcium-dependent enzymes. Bay K8644, as a calcium channel agonist, also increases intracellular calcium, potentially affecting the phosphorylation state of C19orf52. Okadaic Acid, through the inhibition of protein phosphatases PP1 and PP2A, can lead to an overall increase in protein phosphorylation, which may include the phosphorylation of C19orf52. Anisomycin activates the stress-activated protein kinase JNK, which may target C19orf52 for phosphorylation. Lastly, Spermine influences ion channel activity and second messenger systems, which could affect the activation state of C19orf52 through modulation of these signaling pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate target proteins. If C19orf52 is a substrate for PKC, this could lead to its activation through phosphorylation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin acts as an ionophore for calcium, increasing intracellular calcium levels. This can activate calcium-dependent proteins and pathways, such as calmodulin-dependent kinases, which could phosphorylate and activate C19orf52 if it is part of these pathways. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases intracellular cAMP levels, leading to activation of PKA. PKA can then activate proteins, potentially including C19orf52 by phosphorylation if it is within its scope of substrates. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine binds to adrenergic receptors, which can lead to increased cAMP levels and activation of PKA. If C19orf52 is a PKA substrate, it would be activated by PKA-mediated phosphorylation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 acts as an ionophore that allows calcium to enter cells, leading to activation of calcium-dependent signaling pathways. If C19orf52 is regulated by calcium-dependent kinases or phosphatases, this could result in its activation. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a potent activator of the stress-activated protein kinases such as JNK. If C19orf52 is a target for JNK phosphorylation, this would result in its activation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analog that activates PKA. Activation of PKA can result in phosphorylation and activation of C19orf52 if it is a downstream target. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid inhibits protein phosphatases PP1 and PP2A, leading to increased phosphorylation levels of proteins. Persistent phosphorylation can activate proteins like C19orf52 if they are normally dephosphorylated by these phosphatases. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
Bay K8644 acts as a calcium channel agonist, leading to increased intracellular calcium and activation of calcium-dependent enzymes that could phosphorylate and activate C19orf52. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
8-Br-cAMP is a cAMP analog that activates PKA. Through the activation of PKA, it can phosphorylate and potentially activate C19orf52 if it is within the range of PKA targets. | ||||||