C19orf45 Activators
C19orf45 engage distinct cellular signaling pathways to modulate its activity. Forskolin directly stimulates adenylate cyclase, catalyzing the conversion of ATP to cAMP, a key second messenger in cellular signaling. The surge in cAMP levels leads to the activation of protein kinase A (PKA), which can then phosphorylate and activate C19orf45. Similarly, Isoproterenol, by acting on beta-adrenergic receptors, and Dibutyryl-cAMP, a permeable cAMP analog, also lead to PKA activation and subsequent phosphorylation of C19orf45. Likewise, Epinephrine interacts with adrenergic receptors to stimulate adenylate cyclase, increasing cAMP and activating PKA, thereby promoting the activation of C19orf45. IBMX and Theophylline, as phosphodiesterase inhibitors, prevent the degradation of cAMP, indirectly enhancing PKA activity, which in turn can activate C19orf45. Rolipram, which selectively inhibits phosphodiesterase 4, similarly elevates cAMP levels leading to PKA-mediated activation of C19orf45.
Ionomycin and A23187, both of which increase intracellular calcium concentrations, can activate calmodulin-dependent kinase (CaMK) and other calcium-dependent kinases, potentially leading to the phosphorylation and activation of C19orf45. PMA, as an activator of protein kinase C (PKC), initiates a different phosphorylation cascade, which can result in the activation of C19orf45. Ouabain, by inhibiting the Na+/K+-ATPase, indirectly raises intracellular calcium, thereby possibly engaging calcium-dependent signaling mechanisms that lead to the activation of C19orf45. Anisomycin, although primarily known as a protein synthesis inhibitor, can also activate stress-activated protein kinases, such as JNK, which may phosphorylate and activate C19orf45 as part of cellular stress response pathways. Each chemical, through its unique mechanism, ensures that C19orf45 can be activated in a variety of cellular contexts, reflecting the complex regulation of this protein's function in cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a synthetic catecholamine and beta-adrenergic agonist that triggers the beta-adrenergic receptors, resulting in activation of adenylate cyclase and increased cAMP production. The subsequent PKA activation can then phosphorylate and lead to the activation of C19orf45 as part of the cellular response. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentrations. Elevated calcium can activate calmodulin-dependent kinase (CaMK), which may then phosphorylate C19orf45, leading to its functional activation within calcium-dependent signaling pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), which, when activated, can phosphorylate target proteins involved in diverse signaling pathways. PKC-mediated phosphorylation events can lead to the activation of C19orf45 as part of the PKC signaling cascade. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, enzymes that degrade cAMP. By preventing cAMP breakdown, IBMX indirectly raises cAMP levels, which can enhance PKA activity. PKA may then catalyze the phosphorylation and activation of C19orf45 in response to cAMP signaling. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine, also known as adrenaline, interacts with adrenergic receptors to stimulate adenylate cyclase and increase cAMP production. This rise in cAMP activates PKA, which may then engage in the phosphorylation and activation of C19orf45 as part of adrenergic signaling pathways. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that can also activate stress-activated protein kinases like JNK. JNK activation can lead to the phosphorylation of various substrates, potentially including C19orf45, thereby activating it within stress-response signaling pathways. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analog that activates PKA directly, bypassing cell surface receptors and adenylate cyclase. The activated PKA can phosphorylate and activate C19orf45 as part of cAMP-dependent signaling processes. | ||||||
Theophylline | 58-55-9 | sc-202835 sc-202835A sc-202835B | 5 g 25 g 100 g | $20.00 $31.00 $83.00 | 6 | |
Theophylline is a phosphodiesterase inhibitor that leads to increased levels of cAMP within the cell. Similar to IBMX, the increased cAMP levels can result in the activation of PKA, which can then phosphorylate and activate C19orf45 as part of intracellular signaling mechanisms. | ||||||
Ouabain-d3 (Major) | sc-478417 | 1 mg | $506.00 | |||
Ouabain is a cardiac glycoside that inhibits Na+/K+-ATPase, leading to an increase in intracellular sodium levels, which indirectly increases intracellular calcium through the Na+/Ca2+ exchanger. The resultant calcium signaling can activate pathways that include kinases capable of phosphorylating and activating C19orf45. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is an ionophore that selectively transports calcium ions across cell membranes, increasing intracellular calcium levels. This can activate calcium-dependent kinases that may phosphorylate and thus activate C19orf45 within calcium signaling pathways. | ||||||