C17orf80 Inhibitors
C17orf80 is part of a signaling pathway commonly affected by inhibitors of kinases such as PI3K, MEK, or mTOR. These enzymes are involved in crucial cell signaling pathways that regulate cell growth, survival, and proliferation. Inhibitors like Wortmannin and LY294002, which target PI3K, could suppress the PI3K/AKT/mTOR pathway, potentially reducing the phosphorylation states of downstream proteins, including C17orf80 if it is a substrate for AKT. This could lead to decreased cell growth and survival if C17orf80 plays a role in these processes.
If C17orf80 is implicated in the MAPK/ERK pathway, inhibitors like U0126 and PD98059, which target MEK, could block the activation of ERK and subsequent phosphorylation of target proteins, including potentially C17orf80. This might result in altered gene expression and a decrease in cell division if C17orf80 is involved in the cell cycle regulation. Furthermore, if C17orf80 is associated with stress response pathways, JNK inhibitors like SP600125 could prevent its activation, possibly reducing the protein's ability to mediate responses to cellular stressors. For proteins that are part of growth factor signaling, like those modulated by FGFR, an inhibitor like PD173074 could block the pathway, potentially affecting the function of C17orf80 in cell differentiation or angiogenesis. It is also conceivable that, if C17orf80 interacts with cytoskeletal elements or is involved in cell motility, ROCK inhibitors such as Y-27632 might disrupt these processes by preventing the proper functioning of C17orf80.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a steroidal metabolite of fungi, which acts as a potent and irreversible inhibitor of phosphoinositide 3-kinases (PI3Ks). By inhibiting PI3Ks, it can affect downstream signaling cascades possibly related to C17orf80 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a synthetic molecule that selectively inhibits PI3Ks, impacting various signaling pathways, including those that could be modulated by C17orf80. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a pyridinyl imidazole derivative that specifically inhibits p38 MAP kinase, which may impact signaling processes involving C17orf80. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
SP600125 is an anthrapyrazolone inhibitor of c-Jun N-terminal kinase (JNK), potentially altering signaling pathways that C17orf80 may be a part of. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is a macrolide compound that inhibits the mammalian target of rapamycin (mTOR), a key regulatory kinase, potentially affecting C17orf80-related pathways. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a synthetic compound that inhibits MEK, which in turn could modulate the activity of C17orf80 through interference with the ERK pathway. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is a selective inhibitor of Src family tyrosine kinases, which could disrupt signaling mechanisms involving C17orf80. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
Triciribine is a nucleoside analogue that selectively inhibits Akt, which could downregulate pathways potentially associated with C17orf80. | ||||||
PD173074 | 219580-11-7 | sc-202610 sc-202610A sc-202610B | 1 mg 5 mg 50 mg | $46.00 $140.00 $680.00 | 16 | |
PD173074 is a synthetic inhibitor of the fibroblast growth factor receptor (FGFR) tyrosine kinase, which may influence signaling pathways interacting with C17orf80. | ||||||
BIX 02189 | 1094614-85-3 | sc-364436 sc-364436A | 5 mg 10 mg | $220.00 $378.00 | 5 | |
BIX 02189 is a selective inhibitor of MEK5, which could have implications for pathways involving C17orf80, particularly those related to the ERK5 pathway. | ||||||