C14orf43 Activators
C14orf43 Activators encompass a variety of compounds that influence cellular signaling pathways which can indirectly enhance the functional activity of C14orf43. Resveratrol, by activating SIRT1, can lead to the deacetylation of C14orf43, stabilizing the protein and enhancing its interactions within the cell. Similarly, NMN, as a precursor to NAD+, can increase the activity of sirtuins, including SIRT1, and therefore may enhance the functional activity of C14orf43 through deacetylation. AMPK activators such as AICAR, Metformin, and Berberine can phosphorylate downstream targets that interact with C14orf43, possibly enhancing its functional role in energy metabolism and cellular growth.
Curcumin and Spermidine act on acetylation processes; Curcumin through HAT inhibition may decrease acetylation levels of proteins associated with C14orf43, while Spermidine induces autophagy which could lead to increased functional activity of C14orf43 through the removal of aggregated proteins. PPAR activators like Palmitoylethanolamide, Oleoylethanolamide, and ZLN005 can modulate the expression of genes involved in lipid metabolism and energy homeostasis, pathways where C14orf43 could be implicated, thereby indirectly enhancing its activity. Licochalcone A, through STAT3 inhibition, may also upregulate C14orf43 activity by reducing the competitive inhibition for transcriptional coactivators.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, which has been reported to deacetylate specific lysine residues on target proteins, potentially including C14orf43. Deacetylation by SIRT1 can enhance the functional activity of C14orf43 by promoting its stability or altering its interaction with other proteins. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR activates AMPK, which can phosphorylate a variety of downstream targets that may interact with or modulate the activity of C14orf43, thus leading to an enhancement of C14orf43's functional activity in energy metabolism. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $42.00 $62.00 $153.00 $255.00 $500.00 $30.00 | 37 | |
Metformin activates AMPK, which in turn can modulate the functional activity of C14orf43 by altering the cellular energy status and indirectly enhancing its role in cellular processes such as growth and proliferation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can inhibit histone acetyltransferases (HATs), potentially decreasing the acetylation levels of proteins that interact with C14orf43. Reduced acetylation can enhance the activity of C14orf43 by improving its ability to interact with its protein partners. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine is known to induce autophagy via the inhibition of acetyltransferases. Autophagy can modulate protein turnover, including that of C14orf43, potentially increasing its functional activity by removing misfolded or aggregated proteins that may hinder its function. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $92.00 $269.00 $337.00 $510.00 $969.00 | 4 | |
NMN is a precursor of NAD+, which is a substrate for sirtuins. Increased NAD+ levels can activate SIRT1, leading to enhanced deacetylation and subsequent activation of C14orf43 by improving its protein interactions or stability. | ||||||
Palmitoylethanolamide | 544-31-0 | sc-202754 sc-202754A sc-202754B sc-202754C sc-202754D | 10 mg 50 mg 500 mg 1 g 10 g | $78.00 $238.00 $2050.00 $3274.00 $16330.00 | ||
PEA activates PPAR-α, a nuclear receptor that can influence the expression of genes involved in lipid metabolism. Activation of PPAR-α can have downstream effects on C14orf43's activity, particularly in metabolic processes. | ||||||
Oleylethanolamide | 111-58-0 | sc-201400 sc-201400A | 10 mg 50 mg | $88.00 $190.00 | 1 | |
OEA activates PPAR-α, similar to PEA, and can enhance the activity of C14orf43 by influencing the gene expression patterns in lipid metabolism where C14orf43 may play a role. | ||||||
ZLN005 | 49671-76-3 | sc-474381A sc-474381 sc-474381B sc-474381C | 5 mg 10 mg 25 mg 50 mg | $44.00 $112.00 $156.00 $257.00 | ||
ZLN005 is a PPAR-β/δ activator that can modulate the transcription of genes involved in energy metabolism. Through the activation of PPAR-β/δ, ZLN005 can indirectly enhance the functional activity of C14orf43 in related metabolic pathways. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine activates AMPK, which then can enhance the functional activity of C14orf43 through the modulation of cellular energy homeostasis and metabolic pathways where C14orf43 may be implicated. | ||||||