C14orf119 Activators
C14orf119 Activators function through a variety of biochemical mechanisms that lead to its phosphorylation and subsequent increase in activity. One primary route involves the activation of adenylate cyclase, either directly or via adrenergic receptor stimulation, which elevates intracellular levels of cAMP. This rise in cAMP activates protein kinase A (PKA), a kinase that can phosphorylate a wide array of substrates, including C14orf119. This phosphorylation can modulate the protein's functional activity. Moreover, the inhibition of phosphodiesterases results in the accumulation of cAMP and cGMP within the cell, further potentiating the activity of PKA. Similarly, analogs of cAMP that are resistant to degradation can provide a sustained activation signal to PKA, leading to prolonged phosphorylation and activation of C14orf119.
Additionally, the modulation of intracellular calcium levels is another mechanism through which C14orf119 activity can be amplified. Calcium ionophores raise the cytosolic calcium concentration, which can activate calcium-dependent protein kinases capable of phosphorylating C14orf119. This process is further supported by inhibitors of protein phosphatases, resulting in a hyperphosphorylated state of cellular proteins, thereby potentially increasing the phosphorylation and activity of C14orf119. The rise in intracellular calcium not only activates specific kinases but also prompts the release of further signaling molecules, which can interact with and activate a variety of other kinases or signaling pathways that may converge on C14orf119.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Directly activates protein kinase C (PKC). PKC phosphorylation can lead to changes in protein interactions and function. This post-translational modification might increase the activity of C14orf119 through phosphorylation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Selective calcium ionophore which raises intracellular calcium levels, potentially activating calcium-dependent protein kinases that may phosphorylate C14orf119, thus increasing its activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
A synthetic catecholamine that stimulates beta-adrenergic receptors, leading to adenylate cyclase activation. The resulting increase in cAMP can activate PKA, which may then phosphorylate and activate C14orf119. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Nonspecific inhibitor of phosphodiesterases, which prevents the breakdown of cAMP and cGMP, leading to their accumulation. The increased levels of these cyclic nucleotides may enhance PKA activity, potentially activating C14orf119. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A calcium ionophore that increases intracellular calcium levels, potentially activating calcium/calmodulin-dependent kinases which may then phosphorylate and activate C14orf119. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
A potent inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation levels of proteins. This inhibition can result in the hyperphosphorylation and activation of C14orf119. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Adrenergic agonist that activates adenylate cyclase through G protein-coupled receptors, leading to elevated cAMP and subsequent activation of PKA which may phosphorylate and activate C14orf119. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Inhibits protein synthesis and also activates stress-activated protein kinases such as JNK. Activation of these kinases could lead to phosphorylation and activation of C14orf119. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
A cell-permeable cAMP analog that directly activates PKA. The activation of PKA may result in the phosphorylation and activation of C14orf119. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Inhibitor of protein phosphatases, specifically PP1 and PP2A, leading to increased phosphorylation of proteins. This can result in the activation of C14orf119 through a sustained phosphorylation state. | ||||||