C14orf104 Activators
C14orf104 activators encompass a range of compounds that exert their effects through diverse intracellular signaling pathways, ultimately leading to the enhanced activity of C14orf104, a protein critical for dynein arm assembly in cilia. Some activators function by directly elevating the levels of cyclic AMP within cells, thereby engaging protein kinase A (PKA) in phosphorylation events that are pivotal for the assembly and function of dynein arms. Others operate through modulating intracellular calcium levels, which then trigger calcium-dependent signaling cascades that can indirectly influence the activity of C14orf104. This influence is critical given that proper ciliary function is dependent on the precise assembly and stability of dynein arms, which are in turn contingent upon the appropriate phosphorylation and dephosphorylation of specific ciliary proteins.
Furthermore, a subset of activators works through inhibition of phosphodiesterases, leading to an accumulation of cyclic nucleotides that can engage cGMP or cAMP dependent protein kinases, indirectly impacting C14orf104 activity. The modulation of the actin cytoskeleton through inhibition of Rho-kinase also plays a role, as it is crucial for the correct positioning and function of the dynein arms. Additionally, the inhibition of protein phosphatases, which results in prolonged phosphorylation states, can further enhance the activity of C14orf104, emphasizing the intricate balance of phosphorylation within the cellular environment that is essential for the dynamic regulation of ciliary dynein arms.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
A beta-adrenergic agonist that elevates intracellular cyclic AMP, potentially enhancing C14orf104 activity by PKA-dependent phosphorylation processes that are required for dynein arm assembly. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates protein kinase C, which may lead to phosphorylation of proteins involved in dynein arm assembly, indirectly affecting C14orf104 activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Increases intracellular calcium levels, potentially triggering calcium-dependent signaling cascades that indirectly activate C14orf104 by promoting dynein arm assembly or stability. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Inhibits phosphodiesterase-4 and raises cyclic AMP levels, which could enhance C14orf104 activity indirectly by PKA-mediated signaling pathways relevant to dynein arm function. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
A non-specific inhibitor of phosphodiesterases, which could lead to increased cyclic AMP levels and indirectly promote C14orf104 activity via PKA-dependent signaling pathways. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A calcium ionophore that can increase intracellular calcium, potentially indirectly activating C14orf104 through calcium-dependent protein kinases that may be involved in dynein arm assembly. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $103.00 $245.00 | 8 | |
Inhibits phosphodiesterase-5, leading to elevated cyclic GMP levels that could indirectly affect C14orf104 activity through cGMP-dependent protein kinase signaling pathways. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
A Rho-kinase inhibitor that could indirectly enhance C14orf104 activity by modulating actin cytoskeleton dynamics, which is crucial for proper ciliary function and dynein arm placement. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
A cyclic AMP analog that activates PKA and could enhance C14orf104 activity by influencing phosphorylation events that regulate dynein arm assembly and stability. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
A potent inhibitor of protein phosphatases 1 and 2A, which could lead to increased phosphorylation and indirectly enhance C14orf104 activity related to dynein arm assembly. | ||||||