C11orf75_BC017612 Activators
C11orf75_BC017612 can engage in a variety of intracellular signaling cascades to modulate the protein's activity. Forskolin, a potent activator of adenylate cyclase, increases intracellular cAMP levels, which in turn activate protein kinase A (PKA). PKA is known to phosphorylate a multitude of proteins; if C11orf75_BC017612 is a PKA substrate, forskolin can facilitate its activation. Similarly, isoproterenol, a beta-adrenergic agonist, elevates cAMP levels through the stimulation of adenylate cyclase, potentially leading to the activation of C11orf75_BC017612 via PKA. Prostaglandin E2 (PGE2) operates through a comparable mechanism, binding to its EP receptors and initiating a cascade that ultimately increases cAMP and activates PKA, which may then act on C11orf75_BC017612. Dibutyryl cAMP, as a cAMP analog, bypasses the cell surface receptors and directly activates PKA, offering another pathway to C11orf75_BC017612 activation.
Anisomycin, which disrupts protein synthesis, can indirectly activate stress-activated protein kinases like JNK, and if C11orf75_BC017612 is involved in this pathway, anisomycin can lead to its activation. Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which phosphorylates various cellular proteins. If C11orf75_BC017612 is among these substrates, PMA can result in its activation. Ionophores like ionomycin and A23187 raise intracellular calcium levels, which can activate calmodulin-dependent kinases, possibly leading to the activation of C11orf75_BC017612 if it is regulated by calcium signaling. Epidermal Growth Factor (EGF) engages its receptor to initiate the MAPK/ERK pathway, which could encompass the activation of C11orf75_BC017612 if it is situated within this signaling route. Additionally, insulin's activation of the PI3K/AKT pathway can impinge on a broad array of cellular processes, which may include the activation of C11orf75_BC017612 if it is responsive to this pathway. Lastly, retinoic acid modulates gene expression through its nuclear receptors, which could alter the transcriptional level of C11orf75_BC017612, leading to changes in its activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a synthetic catecholamine that activates beta-adrenergic receptors, stimulating adenylate cyclase, increasing cAMP, and consequently activating PKA. If C11orf75_BC017612 is a target of PKA or is regulated by PKA-mediated pathways, isoproterenol can lead to its functional activation through this signaling cascade. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 (PGE2) engages with its G-protein-coupled receptors (EP receptors), which can activate adenylate cyclase, raising the levels of cAMP and activating PKA. Through PKA, PGE2 may activate C11orf75_BC017612 if it is a substrate for PKA or involved in a PKA-regulated process. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
3-Isobutyl-1-methylxanthine (IBMX) is a non-specific inhibitor of phosphodiesterases (PDEs), which prevents the breakdown of cAMP, leading to its accumulation. This increase in cAMP can activate PKA, and subsequently, if C11orf75_BC017612 is a protein that PKA phosphorylates or is involved in a pathway regulated by PKA, IBMX could facilitate its activation. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that can indirectly lead to the activation of stress-activated protein kinases (SAPKs), like JNK. If C11orf75_BC017612 is regulated by or interacts with the JNK pathway, anisomycin could lead to its activation through stress response signaling. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which phosphorylates a broad range of cellular targets. If C11orf75_BC017612 is a substrate for PKC or is within a pathway regulated by PKC, PMA could result in its activation through this kinase's action. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can activate calmodulin-dependent kinases (CaMK), which may activate C11orf75_BC017612 if it is a substrate for CaMK or part of calcium-regulated signaling pathways. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is another calcium ionophore, similar to ionomycin. It increases intracellular calcium and can activate calcium-dependent proteins and pathways. If C11orf75_BC017612 is involved in these pathways or is regulated by calcium-binding proteins such as calmodulin, A23187 could lead to its activation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl cAMP is a membrane-permeable analogue of cAMP that directly activates PKA. If C11orf75_BC017612 is downstream of PKA signaling, dibutyryl cAMP can functionally activate it by simulating the effects of elevated cAMP levels. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin activates the PI3K/AKT signaling pathway, which includes a wide range of downstream effects. If C11orf75_BC017612 is involved in this pathway or is regulated by AKT or downstream components like mTOR, insulin could lead to its activation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid activates nuclear retinoic acid receptors (RARs), which can modulate geneIt seems that your request was cut off before you could finish providing the instructions or inquiry. From the table provided, you have listed a series of compounds along with their CAS numbers and descriptions of their biological activity. If you need information on how these compounds could potentially activate a protein coded by a gene (referenced as C11orf75_BC017612 in the table), you have already outlined the mechanisms by which they might do so. | ||||||