C10orf6 Activators
C10ORF6 activators represent a diverse chemical class designed to modulate cellular mechanisms through the activation of the C10ORF6 protein. This protein is involved in various cellular processes, including those that maintain genomic stability. The activation of C10ORF6 can influence the recruitment and activity of DNA repair complexes, which play a crucial role in the cellular response to DNA damage. By activating C10ORF6, these chemicals can engage the SMC5-SMC6 complex, a critical component for DNA repair, ensuring the proper localization and functional dynamics necessary for maintaining genomic integrity. The influence exerted by these activators on DNA repair pathways is not limited to a single mechanism; instead, it spans a range of biological processes that collectively ensure the effective repair of DNA.
The molecular action of C10ORF6 activators extends to modifying chromatin structure and DNA methylation patterns, key regulatory factors of gene expression and DNA damage response. These activators interact with cellular targets to change the accessibility of repair complexes to chromatin, thereby facilitating the repair process. Additionally, by affecting protein stability and the cell cycle, C10ORF6 activators can enhance the cell's ability to manage DNA errors, ensuring that repair mechanisms are optimally utilized. The changes induced by these activators are not isolated events; they create a cascade of cellular responses that reinforce the structural and functional efficacy of the DNA repair machinery. By engaging C10ORF6, the activators aid in stabilizing the genome through a direct or indirect modulation of the pathways that govern the recognition and correction of DNA lesions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
Inhibiting ATR, this chemical can influence the recruitment and activity of DNA repair complexes, which could possibly activate C10orf6 by affecting the localization and function of the SMC5-SMC6 complex. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
Olaparib, a PARP inhibitor, disrupts DNA repair pathways associated with single-strand break repair. This disruption could possibly activate C10orf6 by increasing reliance on alternative DNA repair mechanisms. | ||||||
ATM Kinase Inhibitor | 587871-26-9 | sc-202963 | 2 mg | $110.00 | 28 | |
KU-55933 targets ATM and its role in the cellular response to double-strand breaks. This action could possibly activate C10orf6 by influencing the dynamics and requirements for the SMC5-SMC6 complex. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Vorinostat modifies chromatin structure and could possibly activate C10orf6 by changing the accessibility of the SMC5-SMC6 complex to its chromatin sites of action. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Decitabine alters DNA methylation and gene expression, which could possibly activate C10orf6 by affecting the DNA damage response and thus the recruitment and activity of the SMC5-SMC6 complex. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide causes double-strand breaks in DNA, which could possibly activate C10orf6 by enhancing the requirement for DNA repair complexes involved in localizing and stabilizing C10orf6. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
By destabilizing proteins involved in DNA repair, 17-AAG could possibly activate C10orf6 through its impact on the function of the SMC5-SMC6 complex. | ||||||
AZD7762 | 860352-01-8 | sc-364423 | 2 mg | $107.00 | ||
AZD7762 inhibits CHK1, potentially causing a shift in DNA repair pathway usage, which could possibly activate C10orf6 in the DNA repair process. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib inhibits protein degradation, which could possibly activate C10orf6 by affecting the turnover of proteins in DNA repair, potentially influencing the activity of DNA repair complexes. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $321.00 | ||
By inhibiting CDK4/6 and potentially altering cell cycle progression, Palbociclib could possibly activate C10orf6 through an increased need for effective DNA repair mechanisms, affecting the SMC5-SMC6 complex's function. | ||||||