C10orf6 Inhibitors
SMC5-SMC6 complex localization factor 2, commonly abbreviated as SLF2, is a protein that plays a crucial role in the maintenance of genomic stability. It is encoded by the SLF2 gene in humans. This protein is known to function as a critical component in the cellular mechanisms that repair DNA and ensure proper chromosomal segregation during cell division.The SMC5-SMC6 complex, to which SLF2 is intricately connected, is part of the structural maintenance of chromosomes (SMC) family, which is essential for chromosome structure and dynamics. The complex itself is involved in the repair of DNA double-strand breaks, the restart of stalled replication forks, and the resolution of recombination intermediates, all of which are vital for the prevention of genomic instability that can lead to cancer and other diseases.
SLF2 works by localizing the SMC5-SMC6 complex to sites of DNA damage, thereby facilitating its function in repair processes. It is thought to act as an adaptor or targeting factor, recognizing specific DNA structures or damage signals and recruiting the complex to these critical areas. This ensures that the SMC5-SMC6 complex is precisely where it needs to be to perform its repair duties effectively.Understanding the function of SLF2 is particularly important in the context of genomic integrity, as it is a key player in safeguarding the genome during replication and in response to DNA damage. Mutations or dysregulation of SLF2 and the SMC5-SMC6 complex are implicated in various human diseases, highlighting the importance of these proteins in cellular health and stability.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MK-886 sodium salt | 118427-55-7 | sc-200608B sc-200608 sc-200608A | 1 mg 5 mg 25 mg | $47.00 $95.00 $378.00 | 3 | |
Inhibits the ATM kinase, a key regulator of the DNA damage response, potentially affecting SMC5-SMC6 complex functions indirectly. | ||||||
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
Targets ATR kinase, another critical protein in DNA damage repair pathways, possibly influencing SMC5-SMC6 activities. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
Inhibits PARP enzymes, involved in single-strand break repair, indirectly affecting DNA repair processes linked to the SMC5-SMC6 complex. | ||||||
NU 7441 | 503468-95-9 | sc-208107 | 5 mg | $357.00 | 10 | |
Specifically inhibits DNA-PKcs, a key player in non-homologous end joining (NHEJ), potentially impacting SMC5-SMC6 complex-related repair mechanisms. | ||||||
LY2606368 | 1234015-52-1 | sc-507521 sc-507521A sc-507521B sc-507521C sc-507521D sc-507521E | 5 mg 10 mg 25 mg 100 mg 1 g 10 g | $176.00 $300.00 $500.00 $1900.00 $8000.00 $25000.00 | ||
Inhibits CHK1, a serine/threonine-specific protein kinase involved in DNA damage checkpoint control, indirectly affecting the SMC5-SMC6 complex pathway. | ||||||
2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1,2-dihydropyrazolo[3,4-d]pyrimidin-3-one | 955365-80-7 | sc-483196 | 5 mg | $340.00 | 1 | |
Targets WEE1 kinase, which regulates cell cycle checkpoints and DNA repair, potentially influencing SMC5-SMC6 complex activities. | ||||||
PNU 120596 | 501925-31-1 | sc-203200 sc-203200A | 1 mg 5 mg | $32.00 $84.00 | 1 | |
Inhibits RAD51 recombinase, crucial for homologous recombination repair, possibly affecting processes involving the SMC5-SMC6 complex. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Targets topoisomerase II, involved in DNA decatenation and chromosome segregation, potentially influencing SMC5-SMC6 complex functions. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $321.00 | ||
Inhibits cyclin-dependent kinases, affecting cell cycle progression and potentially impacting SMC5-SMC6 complex-related mechanisms. | ||||||
BKM120 | 944396-07-0 | sc-364437 sc-364437A sc-364437B sc-364437C | 5 mg 10 mg 25 mg 50 mg | $176.00 $235.00 $281.00 $339.00 | 9 | |
Inhibits PI3K, part of the PI3K/AKT/mTOR pathway, potentially affecting signaling pathways relevant to the SMC5-SMC6 complex. | ||||||