C10orf6 Inhibitors

SMC5-SMC6 complex localization factor 2, commonly abbreviated as SLF2, is a protein that plays a crucial role in the maintenance of genomic stability. It is encoded by the SLF2 gene in humans. This protein is known to function as a critical component in the cellular mechanisms that repair DNA and ensure proper chromosomal segregation during cell division.The SMC5-SMC6 complex, to which SLF2 is intricately connected, is part of the structural maintenance of chromosomes (SMC) family, which is essential for chromosome structure and dynamics. The complex itself is involved in the repair of DNA double-strand breaks, the restart of stalled replication forks, and the resolution of recombination intermediates, all of which are vital for the prevention of genomic instability that can lead to cancer and other diseases.

SLF2 works by localizing the SMC5-SMC6 complex to sites of DNA damage, thereby facilitating its function in repair processes. It is thought to act as an adaptor or targeting factor, recognizing specific DNA structures or damage signals and recruiting the complex to these critical areas. This ensures that the SMC5-SMC6 complex is precisely where it needs to be to perform its repair duties effectively.Understanding the function of SLF2 is particularly important in the context of genomic integrity, as it is a key player in safeguarding the genome during replication and in response to DNA damage. Mutations or dysregulation of SLF2 and the SMC5-SMC6 complex are implicated in various human diseases, highlighting the importance of these proteins in cellular health and stability.