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MK-886 sodium salt, also designated L-663,536, is a potent and selective inhibitor of 5-lipoxygenase-activating protein (FLAP). FLAP is an arachidonic acid binding protein that is critical in the biosynthesis of leukotrienes. Inhibitors of FLAP prevent translocation of 5-lipoxygenase from the cytosol to the membrane and inhibit 5-lipoxygenase (5-LO) activation. MK-886 binds to FLAP with high affinity and prevents the activation of 5-LO, thus inhibiting leukotriene biosynthesis: 2.5 nM in intact leukocytes; 1.1 µM in whole blood. MK-886 sodium salt is an inhibitor of Cox-1, PGE Synthase and PPARα.
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See how others have used MK-886 sodium salt. Click on the entry to view the PubMed entry .
PMID: # 25362851 Xu, Y. et al. 2015. Oncogene. 34: 4229-37.
PMID: # 24167735 Al-Amran, FG. et al. 2013. ISRN Pharmacol. 2013: 303717.
PMID: # 23535410 Takeda, S. et al. 2013. J Toxicol Sci. 38: 305-8.
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