Molecular structure of MK-886 sodium salt, CAS Number: 118427-55-7
MK-886 sodium salt (CAS 118427-55-7)
See product citations (3)
Alternate Names:
3-[1-(p-Chlorobenzyl)-5-(isopropyl)-3-t-butylthioindol-2-yl]-2,2-dimethylpropanoic acid . Na
Application:
MK-886 sodium salt is a potent and selective inhibitor of FLAP and Cox-1
CAS Number:
118427-55-7
Purity:
≥98%
Molecular Weight:
494.06
Molecular Formula:
C27H33ClNO2S•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
MK-886 sodium salt, also designated L-663,536, is a potent and selective inhibitor of 5-lipoxygenase-activating protein (FLAP). FLAP is an arachidonic acid binding protein that is critical in the biosynthesis of leukotrienes. Inhibitors of FLAP prevent translocation of 5-lipoxygenase from the cytosol to the membrane and inhibit 5-lipoxygenase (5-LO) activation. MK-886 binds to FLAP with high affinity and prevents the activation of 5-LO, thus inhibiting leukotriene biosynthesis: 2.5 nM in intact leukocytes 1.1 µM in whole blood. MK-886 sodium salt is an inhibitor of Cox-1, PGE Synthase and PPARalpha.
MK-886 sodium salt (CAS 118427-55-7) References
- FLAP: a novel drug target for inhibiting the synthesis of leukotrienes. | Ford-Hutchinson, AW. 1991. Trends Pharmacol Sci. 12: 68-70. PMID: 2024291
- Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. | Dixon, RA., et al. 1990. Nature. 343: 282-4. PMID: 2300173
- L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor. | Gillard, J., et al. 1989. Can J Physiol Pharmacol. 67: 456-64. PMID: 2548691
Inhibitor of:
5-LO, AADACL4, ABHD12B, Alk-SMase, Alox12e, ALOXE3, C10orf6, C10orf78, COTL1, Cox, Cyp4f14, cytohesin-4, Elastase-B, FABP12, FLAP, group V PLA2, LOX, LPAAT-α, PECR, PGE Synthase, PLCδ1, PLP-Cβ, PLP-Cδ, PPAR beta, PPARα, and PSS2 (PTDSS2; phosphatidylserine synthase 2).Activator of:
Alox12e, CYP4F3, CysLT1 Receptor, LRRC67, MK, and PC-PLD4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MK-886 sodium salt, 1 mg | sc-200608B | 1 mg | $47.00 | |||
MK-886 sodium salt, 5 mg | sc-200608 | 5 mg | $95.00 | |||
MK-886 sodium salt, 25 mg | sc-200608A | 25 mg | $378.00 |