BRAT1 Activators
BRAT1 activators are a class of chemical compounds that enhance the activity of the BRAT1 (BRCA1-associated ATM activator 1) protein, which is encoded by the BRAT1 gene on chromosome 10 in humans. The BRAT1 protein is integral to various cellular functions, including DNA damage response, cell cycle regulation, and apoptosis. It interacts with other key proteins, such as ATM (Ataxia-telangiectasia mutated) and BRCA1, which are involved in maintaining genomic stability. The BRAT1 protein plays a critical role in signaling pathways that monitor and repair DNA damage, helping to preserve the integrity of cellular genetic material. The BRAT1 gene is widely expressed, particularly in tissues with high cellular turnover or metabolic activity, such as the brain.
Activators of BRAT1 are designed to increase the protein's natural activity or enhance its interactions with other cellular components. These compounds can vary chemically, with some activators being small molecules, while others might include larger, more complex entities. Researchers utilize BRAT1 activators to study the upregulation of specific cellular pathways involving BRAT1, shedding light on how this protein influences cellular signaling and stress responses. By examining how these activators impact protein structure and function, scientists can gain a deeper understanding of BRAT1's role in various biological contexts, including its interactions within the DNA damage repair network. The development and study of these activators help to map out the precise biological mechanisms associated with BRAT1's enhanced activity.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, which increases intracellular cAMP levels. Elevated cAMP activates PKA, which can phosphorylate and influence various proteins, potentially leading to the activation of BRAT1 in cellular stress response. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which can activate calcium-dependent protein kinases. These kinases may enhance the activity of BRAT1 by modifying its phosphorylation state. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates SIRT1, which is involved in deacetylating proteins and can influence DNA damage responses and cellular stress pathways that BRAT1 is part of. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is known to inhibit NF-kB signaling, which could shift cellular resources to upregulate stress response pathways, including those involving BRAT1 activation. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane activates Nrf2, leading to the expression of antioxidant response element (ARE)-driven genes. This can indirectly enhance BRAT1's role in cellular defense mechanisms. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG inhibits certain kinases and has been shown to alter signaling pathways involved in cell survival and stress responses, which may indirectly enhance BRAT1 functional activity. | ||||||
Piperlongumine | 20069-09-4 | sc-364128 | 10 mg | $107.00 | ||
Piperlongumine increases ROS levels, which can activate stress response pathways and potentially enhance the activity of BRAT1 in the response to oxidative stress. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin induces ER stress by inhibiting N-linked glycosylation, which may enhance BRAT1 activity as part of the unfolded protein response. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to increased cytosolic calcium levels, potentially enhancing BRAT1's activity in calcium signaling pathways. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
2-Deoxy-D-glucose inhibits glycolysis, leading to energy stress and potentially activating AMPK and subsequent stress response pathways that include BRAT1. | ||||||