BMP-7 Activators
BMP-7, also known as bone morphogenetic protein 7, is a crucial member of the transforming growth factor-beta (TGF-β) superfamily, renowned for its pivotal role in skeletal development and homeostasis. This protein functions as a potent inducer of osteogenesis and chondrogenesis, playing a fundamental role in regulating the differentiation of mesenchymal stem cells into osteoblasts and chondrocytes. Additionally, BMP-7 orchestrates various cellular processes involved in skeletal tissue formation, including cell proliferation, migration, and extracellular matrix synthesis. Its multifaceted functions make BMP-7 indispensable for maintaining skeletal integrity and facilitating bone regeneration processes throughout life.
Activation of BMP-7 involves intricate signaling pathways that converge to stimulate its expression and enhance its biological activity. Key signaling cascades implicated in BMP-7 activation include the TGF-β/Smad, MAPK/ERK, and Wnt/β-catenin pathways, among others. These pathways mediate the transcriptional regulation of BMP-7 gene expression and facilitate post-translational modifications to modulate its signaling efficacy. Through interactions with various receptors and downstream effectors, BMP-7 activation ultimately leads to the initiation of osteogenic and chondrogenic programs, promoting tissue-specific gene expression and cellular differentiation. Understanding the precise mechanisms underlying BMP-7 activation is essential for elucidating its physiological roles.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a natural polyphenol found in various plants, has been shown to activate BMP-7 by enhancing its expression and signaling pathways. It acts through the TGF-β signaling pathway, stimulating BMP-7 production and promoting its downstream effects on bone formation and regeneration. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, an isoflavone found in soy products, activates BMP-7 by upregulating its expression and promoting osteogenic differentiation. It modulates the MAPK/ERK signaling pathway, leading to increased BMP-7 synthesis and activity. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane, a natural compound found in cruciferous vegetables, activates BMP-7 by inducing its expression and enhancing its signaling pathways. It acts through the NRF2-ARE pathway, stimulating BMP-7 production and promoting its osteogenic effects. | ||||||
(−)Epigallocatechin | 970-74-1 | sc-205673 sc-205673A | 1 mg 5 mg | $65.00 $204.00 | 1 | |
Epigallocatechin, a catechin present in green tea, activates BMP-7 by modulating its expression and signaling pathways. It interacts with the Wnt/β-catenin pathway, leading to increased BMP-7 synthesis and activity. | ||||||
Naringin | 10236-47-2 | sc-203443 sc-203443A | 25 g 50 g | $45.00 $101.00 | 7 | |
Naringin, a flavonoid abundant in citrus fruits, activates BMP-7 by promoting its expression and enhancing its signaling cascades. It modulates the PI3K/Akt pathway, leading to increased BMP-7 production and osteogenic differentiation. | ||||||
Piperine | 94-62-2 | sc-205809 sc-205809A | 5 g 25 g | $37.00 $146.00 | 3 | |
Piperine, a bioactive compound found in black pepper, activates BMP-7 by upregulating its expression and augmenting its signaling pathways. It interacts with the JNK signaling pathway, promoting BMP-7 synthesis and osteogenic differentiation. | ||||||
Lycopene | 502-65-8 | sc-205738 sc-205738A sc-205738B | 1 mg 5 mg 1 g | $146.00 $582.00 $6248.00 | 4 | |
Lycopene, a carotenoid pigment abundant in tomatoes, activates BMP-7 by enhancing its expression and signaling cascades. It modulates the NF-κB pathway, promoting BMP-7 production and osteogenic differentiation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid present in various fruits and vegetables, activates BMP-7 by stimulating its expression and signaling pathways. It interacts with the TGF-β/Smad pathway, promoting BMP-7 synthesis and osteogenic effects. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $99.00 $216.00 $510.00 | 11 | |
Kaempferol, a flavonoid abundant in fruits and vegetables, activates BMP-7 by upregulating its expression and enhancing its signaling cascades. It modulates the MAPK/ERK pathway, leading to increased BMP-7 production and osteogenic differentiation. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin, a flavonoid found in parsley and celery, activates BMP-7 by promoting its expression and augmenting its signaling pathways. It interacts with the PI3K/Akt pathway, stimulating BMP-7 synthesis and osteogenic effects. | ||||||