BLM hydrolase Inhibitors
The class of BLMH inhibitors would include a variety of chemical compounds that can interfere with the enzyme's ability to inactivate bleomycin. Since BLMH is a cysteine protease, inhibitors like N-Ethylmaleimide and Iodoacetamide could modify the thiol group of the active site cysteine, rendering the enzyme inactive.
Additionally chemicals such as E-64 and leupeptin, which target cysteine proteases, may also form a covalent bond with the active site cysteine of BLMH. Other protease inhibitors that are not specific to cysteine residues, such as PMSF, aprotinin, and chymostatin, could also inhibit BLMH. Compounds like MG-132 and lactacystin are known to inhibit the proteasome and may affect BLMH through non-specific binding.Overall, BLMH inhibitors would thus be characterized by their ability to bind to and interfere with the active site or other critical regions of the BLM hydrolase enzyme, preventing it from carrying out its normal function of bleomThe protein BLM hydrolase. Direct inhibitors of BLMH could potentiate the activity of bleomycin by preventing its inactivation.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
N-Ethylmaleimide | 128-53-0 | sc-202719A sc-202719 sc-202719B sc-202719C sc-202719D | 1 g 5 g 25 g 100 g 250 g | $22.00 $69.00 $214.00 $796.00 $1918.00 | 19 | |
An alkylating agent that can irreversibly inhibit cysteine proteases; it could interfere with the cysteine residue in the active site of BLMH. | ||||||
α-Iodoacetamide | 144-48-9 | sc-203320 | 25 g | $255.00 | 1 | |
A cysteine alkylator that might inhibit BLMH by modifying the active site cysteine residue, preventing substrate binding. | ||||||
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $281.00 $947.00 $1574.00 | 14 | |
An epoxide-containing compound that irreversibly inhibits cysteine proteases; it could hypothetically react with BLMH's active site cysteine. | ||||||
Leupeptin hemisulfate | 103476-89-7 | sc-295358 sc-295358A sc-295358D sc-295358E sc-295358B sc-295358C | 5 mg 25 mg 50 mg 100 mg 500 mg 10 mg | $73.00 $148.00 $316.00 $499.00 $1427.00 $101.00 | 19 | |
A tripeptide aldehyde that inhibits serine and cysteine proteases; it might bind to the active site of BLMH and inhibit its activity. | ||||||
Phenylmethylsulfonyl Fluoride | 329-98-6 | sc-3597 sc-3597A | 1 g 100 g | $50.00 $697.00 | 92 | |
Phenylmethylsulfonyl fluoride, a serine protease inhibitor that could also affect BLMH if the enzyme has a serine residue critical for its activity. | ||||||
Aprotinin | 9087-70-1 | sc-3595 sc-3595A sc-3595B | 10 mg 100 mg 1 g | $112.00 $408.00 $3000.00 | 51 | |
A proteinaceous inhibitor of proteases that could potentially bind and inhibit BLMH due to its broad specificity. | ||||||
Chymostatin | 9076-44-2 | sc-202541 sc-202541A sc-202541B sc-202541C sc-202541D | 5 mg 10 mg 25 mg 50 mg 100 mg | $156.00 $260.00 $640.00 $1186.00 $2270.00 | 3 | |
A chymotrypsin inhibitor that could hypothetically inhibit BLMH if the enzyme has a similar proteolytic mechanism. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
A potent, reversible proteasome and calpain inhibitor; it could also affect BLMH by binding to its active site. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
An irreversible proteasome inhibitor that could modify the N-terminal threonine of BLMH if it has a similar mechanism. | ||||||
1,10-Phenanthroline | 66-71-7 | sc-255888 sc-255888A | 2.5 g 5 g | $23.00 $32.00 | ||
A metalloprotease inhibitor that chelates zinc; it might affect BLMH if the enzyme is metal-dependent. | ||||||