Chymostatin CAS: 9076-44-2
MF: C25H30N6O5X
An inhibitor of chymotrypsin, papain, and cathepsin G, A, B, H, and L.

Chymostatin (CAS 9076-44-2)

Chymostatin | CAS 9076-44-2 is rated 5.0 out of 5 by 1.
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Synonym: [(S)-1-Carboxy-2-phenylethyl]-carbamoyl-a-[2-amidohexahydro-4(S)-pyrimidyl]-(S)-glycyl-[A= LeuB=Val C=Ile]-phenylalaninal
Application: An inhibitor of chymotrypsin, papain, and cathepsin G, A, B, H, and L
CAS Number: 9076-44-2
Molecular Formula: C25H30N6O5X
* Refer to Certificate of Analysis for lot specific data (including water content).
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Chymostatin is a bioactive peptide protease inhibitor that contains chymostatin A as a major form. The compound specifically inhibits chymotrypsin (CTR) (ID50 = 150 ηg/ml), papain (ID50 = 7.5 μg/ml), and cathepsin G along with most cysteine proteases such as cathepsin A, B, H, and L. The compound has been noted as a strong inhibitor of cathepsins A, B, and C. Chymostatin at an effective concentration of 10 to 100 μM weakly inhibits human leukocyte Elastase-1. In rat muscle homogenates chymostatin inhibited the protease cathepsin B and other soluble Ca2+ activated proteases. In the same study, chymostatin decreased protein break down by 20-40% without inhibiting protein production.


References

1. Umezawa, H., et al. 1970. J. Antibiot. 23: 425-427. PMID: 5453321
2. Tatsuta, K., et al. 1973. J. Antibiot. 26: 625-646. PMID: 4792111
3. Feinstein, G., et al. 1976. Biochim. Biophys. Acta. 429: 925-932. PMID: 1083745
4. Libby, P. and Goldberg, A.L. 1980. Biochem. J. 188: 213-220. PMID: 7406880
5. Murakami, T., et al. 1991. Biochim. Biophys. Acta. 1079: 279-284. PMID: 1911851

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (10 mM), glacial acetic acid (10 mg/ml), water (slightly), and 0.1 M HCl. Insoluble in ethyl acetate, butyl acetate, ether, hexane, and petroleum ether.
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
GC3047700
PubChem CID :
443119
MDL Number :
MFCD00071059
SMILES :
CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C=O)NC(=O)C(C2CCN=C(N2)N)NC(=O)NC(CC3=CC=CC=C3)C(=O)O

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Certificate of Analysis

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Chymostatin  Product Citations

See how others have used Chymostatin. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 24531472  Kohler, AC. et al. 2014. Acta Crystallogr. D Biol. Crystallogr. 70: 384-91.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Roszkowska Roszkowska-Chojecka, MM. et al. (PubMed 26011164) investigated the effects of Chymostatin, a chymase inhibitor, on blood pressure, plasma and tissue angiotensin II, renal haemodynamics and renal excretion in two models of hypertension in the rat. They concluded that Chymase or similar chymostatin-sensitive enzyme(s) has a significant role in the synthesis of Ang II in different tissues but does not participate in short-term control of blood pressure in salt-dependent or Goldblatt-type rat hypertension. -SCBT Publication Review
Date published: 2015-04-13
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