Molecular structure of Chymostatin, CAS Number: 9076-44-2
Chymostatin (CAS 9076-44-2)
See product citations (3)
Alternate Names:
[(S)-1-Carboxy-2-phenylethyl]-carbamoyl-a-[2-amidohexahydro-4(S)-pyrimidyl]-(S)-glycyl-[A= LeuB=Val C=Ile]-phenylalaninal
Application:
Chymostatin is an inhibitor of chymotrypsin, papain, and cathepsin G, A, B, H, and L
CAS Number:
9076-44-2
Molecular Weight:
607.7
Molecular Formula:
C31H41N7O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Chymostatin is a bioactive peptide protease inhibitor that contains chymostatin A as a major form. The compound specifically inhibits chymotrypsin (CTR) (ID50 = 150 etag/ml), papain (ID50 = 7.5 mug/ml), and cathepsin G along with most cysteine proteases such as cathepsin A, B, H, and L. The compound has been noted as a strong inhibitor of cathepsins A, B, and C. Chymostatin at an effective concentration of 10 to 100 muM weakly inhibits human leukocyte Elastase-1. In rat muscle homogenates chymostatin inhibited the protease cathepsin B and other soluble Ca2+ activated proteases. In the same study, chymostatin decreased protein break down by 20-40% without inhibiting protein production.
Chymostatin (CAS 9076-44-2) References
- The inhibition of human leucocyte elastase and chymotrypsin-like protease by elastatinal and chymostatin. | Feinstein, G., et al. 1976. Biochim Biophys Acta. 429: 925-32. PMID: 1083745
- A principal neutralizing domain of human immunodeficiency virus type 1 interacts with proteinase-like molecule(s) at the surface of Molt-4 clone 8 cells. | Murakami, T., et al. 1991. Biochim Biophys Acta. 1079: 279-84. PMID: 1911851
- Effects of chymostatin, a chymase inhibitor, on blood pressure, plasma and tissue angiotensin II, renal haemodynamics and renal excretion in two models of hypertension in the rat. | Roszkowska-Chojecka, MM., et al. 2015. Exp Physiol. 100: 1093-105. PMID: 26011164
- The effect of analogues of chymostatin on lysosomal and non-lysosomal components of protein degradation in isolated hepatocytes. | Place, GA., et al. 1987. Biochim Biophys Acta. 925: 185-93. PMID: 2887208
- Protective Effects of Chymostatin on Paraquat-Induced Acute Lung Injury in Mice. | Yang, C., et al. 2018. Inflammation. 41: 122-133. PMID: 28940034
- Combination of Chymostatin and Aliskiren attenuates ER stress induced by lipid overload in kidney tubular cells. | Qiu, M., et al. 2018. Lipids Health Dis. 17: 183. PMID: 30064425
- Decoding the Papain Inhibitor from Streptomyces mobaraensis as Being Hydroxylated Chymostatin Derivatives: Purification, Structure Analysis, and Putative Biosynthetic Pathway. | Juettner, NE., et al. 2020. J Nat Prod. 83: 2983-2995. PMID: 32998509
- Chymostatin has no apparent beneficial effect on muscular dystrophy in the mdx mouse. | Christie, KN. 1988. J Neurol Sci. 84: 341-6. PMID: 3379449
- Beneficial effect of chymostatin on dystrophic mice. | Komatsu, K., et al. 1986. Exp Neurol. 93: 110-6. PMID: 3732454
- The structure of chymostatin, a chymotrypsin inhibitor. | Tatsuta, K., et al. 1973. J Antibiot (Tokyo). 26: 625-46. PMID: 4792111
- Chymostatin, a new chymotrypsin inhibitor produced by actinomycetes. | Umezawa, H., et al. 1970. J Antibiot (Tokyo). 23: 425-7. PMID: 5453321
- Effects of chymostatin and other proteinase inhibitors on protein breakdown and proteolytic activities in muscle. | Libby, P. and Goldberg, AL. 1980. Biochem J. 188: 213-20. PMID: 7406880
Inhibitor of:
α2-Macroglobulin, α2ML1, 5430419D17Rik, Antipain dihydrochloride, ASTL, BC048546, BLM hydrolase, cathepsin A, cathepsin B, cathepsin C, cathepsin G, cathepsin H, cathepsin L, CCP2, Chymostatin, Chymotrypsin, CLAP, CLPSL1, CPA2, CPA5, CPAMD8, cystatin 10, ENSMUSG00000071517, Enterokinase, Gm46, granzyme A, granzyme D, granzyme E, granzyme G, granzyme H, granzyme M, granzyme N, HtrA2, HtrA4, Jade-1, Kex2, Kininogen II, KLK (Kallikrein related peptidase), Klk1b4, Klk26, KLKb2, LOC150935, LOC728400, LRRC42, Marapsin 2, Mast Cell Protease, Mast Cell Protease 8, MC-CPA, mCST E2, megsin, Mesotrypsinogen, MUP2, MUP3, MUP4, murinoglobulin 2, neuroserpin, Neurotrypsin, ORAOV1, OTTMUSG00000016293, OVCA2, P-Rex2, Papain, PRB1-3, PRB2, PRB3, Pronase, Protease, Prss29, Prss32, PRSS33, Prss34, PRSS37, Prss39, Prss47, PRSS50, PRSSL1, RHBDL2, SCGB1D4, Sel-1L3, SerpinA1b, SerpinA1e, SerpinA2, SerpinA3n, SerpinB1b, Serpinb3c, Serpinb3d, SerpinB6B, SerpinB6C, Serpinb6d, SerpinB6e, SerpinB8, Spi10, SPINK10, SPINK14, SPINK2, SPINK6, SPINK7, SPUVE, stefin A1L1, stefin A2, stefin A3L1, TESP3, TLCK, TMPRSS11E, TMPRSS11F, TMPRSS12, TPCK, TRIM50, Trypsin X3, Trypsin-1, Trypsin-4, Trypsin-5, Tryptase γ, V3R 2, Vmn2r62, Vmn2r70, Vrho, WFDC17, ZFP30, and ZP4.Activator of:
APEH, Chromozym TRY, CPA1, cystatin 9, cystatin B, HAI-1, KLK9, LOC646960, PACE4, PN-1, SerpinA3i, SerpinB6C, stefin A1L1, TMPRSS11B, TMPRSS11E2, TMPRSSs8, TPPII, and TPSB1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Chymostatin, 5 mg | sc-202541 | 5 mg | $153.00 | |||
Chymostatin, 10 mg | sc-202541A | 10 mg | $255.00 | |||
Chymostatin, 25 mg | sc-202541B | 25 mg | $627.00 | |||
Chymostatin, 50 mg | sc-202541C | 50 mg | $1163.00 | |||
Chymostatin, 100 mg | sc-202541D | 100 mg | $2225.00 |