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Phenylmethylsulfonyl Fluoride (PMSF) is an irreversible inhibitor of serine proteases, such as trypsin, chymotrypsin, and thrombin. It also inhibits acetylcholinesterase (AChE) and phospholipase C (PLC). It affords alkenes by reacting with carbonyl compounds and causes sulfonylation of the active-site serine residues. PMSF also inhibits most cysteine proteases like papain. Commonly used in the preparation of cell lysates to inhibit protein digestion. PMSF can substitute for diisopropylfluorophosphate (DFP; sc-203922), and also inhibits metalloproteases and aspartic proteases. It is a widely used fatty acid amid hydrolase (FAAH) inhibitor for pretreatment of brain membrane preparations when testing CB1 receptor activity.
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See how others have used Phenylmethylsulfonyl Fluoride. Click on the entry to view the PubMed entry .
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PMID: # 28277608 Mot, A.C. et al. 2017. The New phytologist.
PMID: # 27760898 Mitsui, T.|Ishida, M.|Izawa, M.|Arita, J.| et al. 2017. Endocr. J. 64: 103-115.
PMID: # 27030360 Hasanpourghadi, M. et al. 2016. J. Exp. Clin. Cancer Res. 35: 58.
PMID: # 26798350 Madhu, V. et al. 2016. Stem Cells Int. 2016: 1035374.
PMID: # 27113095 Boriushkin, E. et al. 2016. Sci Rep. 6: 25013.
PMID: # 27114691 Nardi, GM. et al. 2016. Pharmacognosy Res. 8: S42-9.
PMID: # 26778787 Targowska-Duda, KM. et al. 2016. Behavioural brain research. 302: 142-51.
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