Phenylmethylsulfonyl Fluoride CAS: 329-98-6
MF: C7H7FO2S
MW: 174.19
An irreversible serine protease and FAAH inhibitor.

Phenylmethylsulfonyl Fluoride (CAS 329-98-6)

Phenylmethylsulfonyl Fluoride | CAS 329-98-6 is rated 5.0 out of 5 by 1.
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Synonym: PMSF
Application: An irreversible serine protease and FAAH inhibitor
CAS Number: 329-98-6
Purity: ≥99%
Molecular Weight: 174.19
Molecular Formula: C7H7FO2S
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Phenylmethylsulfonyl Fluoride (PMSF) is an irreversible inhibitor of serine proteases, such as trypsin, chymotrypsin, and thrombin. It also inhibits acetylcholinesterase (AChE) and phospholipase C (PLC). It affords alkenes by reacting with carbonyl compounds and causes sulfonylation of the active-site serine residues. PMSF also inhibits most cysteine proteases like papain. Commonly used in the preparation of cell lysates to inhibit protein digestion. PMSF can substitute for diisopropylfluorophosphate (DFP; sc-203922), and also inhibits metalloproteases and aspartic proteases. It is a widely used fatty acid amid hydrolase (FAAH) inhibitor for pretreatment of brain membrane preparations when testing CB1 receptor activity.


References

1. Tsang, V.C., et al. 1989. J. Infect. Dis. 159: 50-59. PMID: 2909643
2. Nam, K.H., et al. 2009. Biochem. Biophys. Res. Commun. 389: 247-250. PMID: 19715665
3. Krishnan, N., et al. 2009. J. Biol. Chem. 284: 16066-16070. PMID: 19351884

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in ether, benzene, (anhydrous 2-propanol (200 mM), anhydrous methanol (200 mM), anhydrous ethanol (200 mM),Stock solution are stable for months at 4°C) water(unstable), and toluene.
Storage :
Store at 4° C
Melting Point :
92-94° C
Boiling Point :
85° C (lit.) at 0.3 mmHg
Density :
1.32 g/cm3 (Predicted)
Refractive Index :
n20D 1.52 (Predicted)
IC50 :
Anandamide amidohydrolase: IC50 = 13 µM (human); Leukocyte elastase: IC50 = 52.2 µM (human)
Ki Data :
chymotrypsin : Ki= 13 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
XT8040000
PubChem CID :
4784
Merck Index :
14: 7542
MDL Number :
MFCD00007424
EC Number :
206-350-2
Beilstein Registry :
2088311
SMILES :
C1=CC=C(C=C1)CS(=O)(=O)F

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Certificate of Analysis

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Phenylmethylsulfonyl Fluoride  Product Citations

See how others have used Phenylmethylsulfonyl Fluoride. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 60 total

PMID: # 30389374  Virgolini, MJ.|Feliziani, C.|Cambiasso, MJ.|Lopez, PH.|Bollo, M.| et al. 2019. Biochim Biophys Acta Mol Cell Res. 1866: 225-239.

PMID: # 31441677  2019. Am. J. Physiol. Heart Circ. Physiol. 29: 818-26.

PMID: # 28494010  Okubo, Y. et al. 2017. PLoS ONE. 12: e0177375.

PMID: # 28277608  Mot, A.C. et al. 2017. The New phytologist.

PMID: # 27760898  Mitsui, T.|Ishida, M.|Izawa, M.|Arita, J.| et al. 2017. Endocr. J. 64: 103-115.

PMID: # 27030360  Hasanpourghadi, M. et al. 2016. J. Exp. Clin. Cancer Res. 35: 58.

PMID: # 26798350  Madhu, V. et al. 2016. Stem Cells Int. 2016: 1035374.

PMID: # 27113095  Boriushkin, E. et al. 2016. Sci Rep. 6: 25013.

PMID: # 27114691  Nardi, GM. et al. 2016. Pharmacognosy Res. 8: S42-9.

PMID: # 26778787  Targowska-Duda, KM. et al. 2016. Behavioural brain research. 302: 142-51.

Citations 1 to 10 of 60 total
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Rated 5 out of 5 by from Gohil Gohil, K. et al. (PubMed 18299118) used product sc-3597 (Phenylmethylsulfonyl Fluoride), a chemical that inhibits Ser proteases like chymotrypsin, trypsin, and thrombin and most cysteine proteases, like papain, to prevent tissue degradation. -SCBT Publication Review
Date published: 2015-01-24
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