βB2-crystallin Activators
βB2-crystallin activators comprise a diverse class of chemicals, primarily characterized by their ability to influence cellular pathways that indirectly impact the function and stability of βB2-crystallin. The majority of these compounds exert their effects through modulation of oxidative stress, inflammation, and cellular aging processes. For instance, compounds like epigallocatechin gallate, resveratrol, and curcumin engage with cellular pathways to mitigate oxidative damage, a key factor in maintaining the structural integrity and function of βB2-crystallin in the lens. This action is crucial, as oxidative stress is a major contributor to lens opacification and cataract formation.
The second characteristic feature of this chemical class is the modulation of nutritional and metabolic pathways, as exemplified by compounds like retinoic acid, zinc, and selenium. These activators contribute to the overall health of ocular tissues, with a specific focus on ensuring the proper folding and function of lens proteins such as βB2-crystallin. The involvement of these compounds in cellular defense mechanisms, including those against UV-induced damage and age-related degeneration, highlights their integral role in preserving the clarity and functionality of the ocular lens.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
A major component of green tea, this compound influences antioxidant pathways, which can indirectly affect βB2-crystallin by reducing oxidative stress in ocular cells. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Found in grapes, it activates SIRT1, a protein that plays a role in cellular stress resistance and longevity, potentially enhancing the stability and function of βB2-crystallin. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
A compound from turmeric, curcumin modulates NF-κB pathway, which is involved in inflammatory responses, potentially impacting the expression of βB2-crystallin. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
A flavonoid with antioxidant properties, it modulates cellular stress responses, which could indirectly stabilize βB2-crystallin in ocular cells. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Found in cruciferous vegetables, it activates Nrf2, a key regulator of the antioxidant response, potentially enhancing βB2-crystallin's resistance to oxidative damage. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
A flavonoid present in many plants, luteolin has anti-inflammatory effects that might influence βB2-crystallin expression or stability in eye tissues. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
A derivative of Vitamin A, it plays a crucial role in eye development and maintenance, potentially influencing βB2-crystallin expression. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
An essential mineral that plays a role in enzyme function and protein folding, zinc may influence the structural integrity of βB2-crystallin. | ||||||
Selenium | 7782-49-2 | sc-250973 | 50 g | $62.00 | 1 | |
An antioxidant trace element, selenium could contribute to the maintenance of βB2-crystallin structure and function in the lens. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
An essential nutrient and antioxidant, Vitamin C might protect βB2-crystallin from oxidative stress in the lens. | ||||||