BET5 Inhibitors
BET5 inhibitors primarily focus on the disruption or modulation of vesicular transport pathways, especially between the endoplasmic reticulum (ER) and the Golgi apparatus, given that BET5 plays a crucial role within this cellular process. The intent behind targeting these pathways is to influence the activity or functionality of BET5 indirectly. Brefeldin A and Monensin, for example, are instrumental in this regard. Brefeldin A collapses the Golgi structure and hampers transport from the ER, thereby impacting BET5's functionality, while Monensin disrupts vesicular transport, thereby potentially impacting BET5's transport role.
Microtubules and actin filaments, being structural components essential for vesicular transport, are another focal point. Nocodazole, which depolymerizes microtubules, and Latrunculin A, an actin filament disruptor, are indicative of the strategy to hinder these structural components and, by extension, the transport processes BET5 is involved in. Additionally, compounds like Thapsigargin and Tunicamycin induce ER stress, offering a different angle to modulate BET5's role.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Disrupts the structure of the Golgi apparatus and blocks transport from the ER to the Golgi. Since BET5 is involved in vesicle transport between these organelles, Brefeldin A can indirectly modulate its function. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Sodium ionophore that disrupts vesicular transport between the ER and Golgi. Its effect on this transport can indirectly impact the role of BET5 in this process. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Depolymerizes microtubules, which are essential for vesicular transport. This disruption can indirectly affect the role of BET5 in vesicle transport. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Induces ER stress by inhibiting the SERCA pump, leading to calcium depletion. This stress can impact vesicle transport processes in which BET5 is involved. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Induces ER stress by inhibiting N-linked glycosylation. This can have indirect effects on the vesicle transport roles of BET5. | ||||||
Golgicide A | 1005036-73-6 | sc-215103 sc-215103A | 5 mg 25 mg | $187.00 $670.00 | 11 | |
Targets the Arf guanine nucleotide exchange factors, disrupting Golgi structure and function. By affecting the Golgi's functionality, it can indirectly influence the role of BET5 in vesicle transport. | ||||||
Exo1 | 461681-88-9 | sc-200752 sc-200752A | 10 mg 50 mg | $82.00 $291.00 | 3 | |
Disrupts the secretion of vesicles from the ER. By affecting this secretion, it can indirectly modulate BET5's involvement in the process. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $92.00 $182.00 | 71 | |
A protein kinase A inhibitor. Since PKA can influence various cellular processes including vesicular transport, inhibiting it can indirectly affect BET5 function. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $134.00 $502.00 | 7 | |
An inhibitor of the Cdc42 GTPase. Given that Cdc42 plays roles in vesicle transport and Golgi functionality, inhibiting this protein can indirectly influence BET5. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Disrupts actin filaments which are necessary for various cellular transport mechanisms. This can indirectly modulate the processes BET5 is involved in. | ||||||