BET5 Activators
BET5 activators are compounds that modulate cellular pathways impacting the function and regulation of the trafficking protein particle complex subunit BET5, a crucial component of the vesicular trafficking machinery. These activators are not direct stimulants of the protein; instead, they exert their effects by altering the cellular environment or signaling pathways, thereby influencing BET5 activity. The primary method by which these chemicals act is by inducing cellular stress responses, such as the unfolded protein response (UPR), or by affecting organelle function, which can lead to compensatory mechanisms that potentially enhance the function or expression of trafficking components like BET5.
Compounds like Forskolin and GTPγS act indirectly by modulating signaling pathways and biochemical processes such as cAMP levels and GTPase activity, respectively, which are integral to vesicular trafficking. Additionally, responses to environmental changes, such as temperature shifts and hypotonic shock, can also affect cellular trafficking dynamics, thereby influencing BET5 activity.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
An activator of adenylate cyclase that can raise intracellular cAMP levels, potentially influencing cellular processes including vesicular trafficking, which could have downstream effects on BET5 function. | ||||||
Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt | 94825-44-2 | sc-202639 | 10 mg | $456.00 | ||
A non-hydrolyzable analogue of GTP that can activate GTPases involved in vesicular trafficking, potentially leading to increased demand for trafficking components, including BET5. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
An inhibitor of glycogen synthase kinase-3 (GSK-3), which can affect various cellular processes, including vesicular trafficking, potentially influencing the function of trafficking complexes like TRAPP and BET5. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor that can lead to the accumulation of misfolded proteins, invoking the unfolded protein response (UPR) and potentially enhancing the expression of proteins involved in vesicular trafficking like BET5 to cope with increased protein load. | ||||||