BET5 Antibody (B-4): sc-377024

BET5 Antibody (B-4) is a mouse monoclonal IgM antibody that detects BET5 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BET5 (B-4) antibody is available as the non-conjugated form. BET5, also known as TRAPPC1 (Trafficking protein particle complex subunit 1) and MUM2 (Multiple myeloma protein 2), plays a critical role in vesicular transport, essential for proper functioning and survival of eukaryotic cells. BET5 functions as a key component of TRAPP I (transport protein particle I) multi-subunit complex on the Golgi apparatus, facilitating tethering of endoplasmic reticulum-to-Golgi vesicles to target membranes. This tethering process ensures specificity of vesicle transport, preventing misdelivery of cellular cargo. BET5 gene is situated on human chromosome 17, a region encompassing over 2.5% of the human genome and responsible for encoding more than 1,200 genes. Understanding BET5 function and interactions within TRAPP complex remains crucial for elucidating mechanisms underlying intracellular transport and implications in various cellular processes and diseases.

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BET5 Antibody (B-4) References:

1. Two antigens recognized by autologous cytolytic T lymphocytes on a melanoma result from a single point mutation in an essential housekeeping gene.  |  Chiari, R., et al. 1999. Cancer Res. 59: 5785-92. PMID: 10582700
2. Functional organization of the yeast proteome by systematic analysis of protein complexes.  |  Gavin, AC., et al. 2002. Nature. 415: 141-7. PMID: 11805826
3. Vesicle tethering complexes in membrane traffic.  |  Whyte, JR. and Munro, S. 2002. J Cell Sci. 115: 2627-37. PMID: 12077354
4. The TRAPP complex: insights into its architecture and function.  |  Sacher, M., et al. 2008. Traffic. 9: 2032-42. PMID: 18801063
5. Immunochemotherapy for Bcl-2 and MUM-negative aggressive primary cutaneous B-cell non-Hodgkin's lymphoma.  |  Colovic, N., et al. 2009. Arch Dermatol Res. 301: 689-92. PMID: 19495780
6. A high copy suppressor screen reveals genetic interactions between BET3 and a new gene. Evidence for a novel complex in ER-to-Golgi transport.  |  Jiang, Y., et al. 1998. Genetics. 149: 833-41. PMID: 9611195

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BET5 Antibody (B-4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-BET5 Antibody (B-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

BET5 Antibody (B-4) Specifications

Alternate Product Name: BET5

Product Clone Name: B-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 101-133

Epitope Target: BET5

Epitope Species: human

Product Reactivity/Detection: BET5

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for BET5 Antibody (B-4): P: Blocking Peptide