Bestrophin-1 Activators
The chemical class of"Bestrophin-1 Activators encompasses a diverse range of compounds that could potentially influence the activity of Bestrophin-1 indirectly. Bestrophin-1 is crucial in the regulation of chloride channels and is associated with the physiological processes in retinal pigment epithelial cells. The modulation of Bestrophin-1 is intricately linked to intracellular calcium dynamics and various cellular signaling pathways.
Compounds such as Forskolin, which increases cAMP levels, and Genistein, a tyrosine kinase inhibitor, demonstrate their potential to influence Bestrophin-1 activity through modulation of specific signaling pathways. Forskolin's role in elevating cAMP levels and Genistein's impact on tyrosine kinase-mediated signaling highlight the complex interplay between cellular signaling and the regulation of ion channels like Bestrophin-1. Additionally, calcium modulators like BAPTA-AM, Dantrolene, EGTA, Verapamil, and Nitrendipine could play a role in modulating Bestrophin-1 activity through their effects on calcium signaling. These compounds, by influencing intracellular calcium levels and calcium channel activity, provide insights into the indirect mechanisms through which Bestrophin-1 can be influenced.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Increases cAMP levels, potentially influencing Bestrophin-1 activity through cAMP-dependent pathways. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
A tyrosine kinase inhibitor, might indirectly affect Bestrophin-1 through cellular signaling pathways. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
A calcium chelator, might influence Bestrophin-1 by altering intracellular calcium levels. | ||||||
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
Reduces intracellular calcium release, potentially affecting Bestrophin-1 activity. | ||||||
EGTA | 67-42-5 | sc-3593 sc-3593A sc-3593B sc-3593C sc-3593D | 1 g 10 g 100 g 250 g 1 kg | $20.00 $62.00 $116.00 $246.00 $799.00 | 23 | |
Another calcium chelator, could indirectly affect Bestrophin-1 by modulating calcium signaling. | ||||||
Ibuprofen | 15687-27-1 | sc-200534 sc-200534A | 1 g 5 g | $52.00 $86.00 | 6 | |
An NSAID, could indirectly influence Bestrophin-1 through effects on cellular signaling and ion channels. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Modulates various signaling pathways, potentially influencing Bestrophin-1 activity. | ||||||
Gallotannin | 1401-55-4 | sc-202619 sc-202619A sc-202619B sc-202619C sc-202619D sc-202619E sc-202619F | 1 g 10 g 100 g 250 g 1 kg 2.5 kg 5 kg | $25.00 $36.00 $66.00 $76.00 $229.00 $525.00 $964.00 | 12 | |
Known to interact with proteins and enzymes, might influence Bestrophin-1 indirectly. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
A calcium channel blocker, could affect Bestrophin-1 activity by altering calcium dynamics. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Influences various signaling pathways, potentially modulating Bestrophin-1 activity. | ||||||