BECN1L1 Activators
BECN1L1, a homolog of Beclin 1, plays a pivotal role in the regulation of autophagy, a cellular process critical for maintaining homeostasis and cell survival under stress. Autophagy activators like Rapamycin and Torin 1 target the mTOR pathway, a central negative regulator of autophagy. Rapamycin binds to and inhibits mTOR, thereby lifting its suppressive effect on the autophagic machinery and enhancing BECN1L1 activity. Similarly, Torin 1 acts as a potent mTOR inhibitor, further promoting autophagy and increasing BECN1L1 function. These inhibitors, by blocking the mTOR pathway, could lead to the initiation of autophagy and provide a conducive environment for BECN1L1 activity.
On the other hand, autophagy modulation through different mechanisms can also impact BECN1L1 activity. Perifosine, an Akt inhibitor, attenuates the inhibition of autophagy mediated by Akt, which may result in enhanced BECN1L1 function. Trehalose initiates autophagy through an mTOR-independent mechanism, suggesting an alternative route to activate BECN1L1. Additionally, sirtuin modulators such as Nicotinamide and Resveratrol can influence autophagy through changes in the acetylation status of proteins, which in turn may affect BECN1L1. Lithium chloride induces autophagy via the IP3 pathway, providing yet another pathway that may lead to the enhancement of BECN1L1 activity. These diverse compounds indicate multiple pathways and molecular targets through which BECN1L1 activity could be modulated.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a known negative regulator of autophagy. BECN1L1 is a homolog of Beclin 1, which is involved in autophagy initiation. Inhibition of mTOR by Rapamycin would enhance autophagic processes, thereby potentially increasing BECN1L1 activity. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $240.00 | 7 | |
Torin 1 is another potent inhibitor of mTOR, which could similarly enhance autophagy by disinhibiting the pathway, potentially leading to increased activity of BECN1L1. | ||||||
Perifosine | 157716-52-4 | sc-364571 sc-364571A | 5 mg 10 mg | $184.00 $321.00 | 1 | |
Perifosine is an Akt inhibitor; Akt is a kinase that can inhibit autophagy when activated. By inhibiting Akt, Perifosine may promote autophagy, thereby possibly enhancing BECN1L1 function. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $56.00 $256.00 | 113 | |
3-Methyladenine (3-MA) inhibits PI3K, which is involved in autophagy inhibition. Although typically used to inhibit autophagy, at low concentrations, it can paradoxically induce autophagy, potentially enhancing the activity of BECN1L1. | ||||||
Spautin-1 | 1262888-28-7 | sc-507306 | 10 mg | $165.00 | ||
Spautin-1 promotes the degradation of PI3K class III and Beclin 1 complex components. This might indirectly enhance BECN1L1 activity by shifting cellular autophagy balance. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor which, similar to 3-MA, could at certain concentrations or contexts indirectly stimulate autophagy, potentially increasing BECN1L1 activity. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine inhibits the fusion of autophagosomes with lysosomes. By accumulating autophagic vesicles, it may indirectly increase the demand for autophagy-related proteins, such as BECN1L1. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1, like Chloroquine, prevents the fusion of autophagosomes with lysosomes. This could also possibly elevate the functional demand for autophagy-related proteins including BECN1L1. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Nicotinamide is a sirtuin inhibitor which can lead to increased acetylation of proteins involved in autophagy. This could potentially enhance BECN1L1 function by increasing autophagy. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates sirtuins, which can deacetylate proteins and enhance autophagy. Through this sirtuin-mediated pathway, BECN1L1 activity could be increased. | ||||||