BBS5 Inhibitors
BBS5 inhibitors are a class of chemical compounds that specifically target and inhibit the BBS5 protein, which is one of the components of the Bardet-Biedl syndrome (BBS) complex. BBS5 is involved in the regulation and functioning of primary cilia, which are sensory organelles present on the surface of most eukaryotic cells. These cilia play critical roles in cellular signaling, particularly in relation to environmental sensing and cellular communication. BBS5 is responsible for mediating protein-protein interactions within the BBSome, a complex that facilitates the trafficking of proteins to the cilia. Inhibitors of BBS5 disrupt this function by interfering with its ability to interact with other proteins in the BBSome, ultimately affecting the stability and function of the primary cilia.
The chemical structure of BBS5 inhibitors often includes small molecules designed to specifically bind to critical regions of the BBS5 protein, such as its interaction domains with other components of the BBSome. These inhibitors may act by directly blocking the binding sites necessary for complex formation or by inducing conformational changes that reduce the functionality of BBS5. By inhibiting BBS5, researchers can gain insights into how the BBSome complex is regulated and how defects in protein trafficking to the primary cilia impact broader cellular processes. The study of BBS5 inhibitors is important for understanding the role of cilia in cell signaling and homeostasis, as well as the intricate network of proteins that contribute to the maintenance and function of these organelles. Through the use of these inhibitors, scientists can explore the specific contributions of BBS5 to cellular organization and signaling pathways associated with ciliary function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent inhibitor of phosphoinositide 3-kinases (PI3Ks). PI3Ks generate phosphatidylinositol (3,4,5)-trisphosphate (PIP3), which is required for localization of some proteins to the cilium. By inhibiting PI3Ks, Wortmannin can indirectly lead to decreased ciliary localization of BBS5. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is another PI3K inhibitor. Like Wortmannin, it can indirectly inhibit BBS5 function by reducing PIP3 levels and thereby affecting ciliary localization of BBS5. | ||||||
Propranolol | 525-66-6 | sc-507425 | 100 mg | $180.00 | ||
Propranolol is a non-selective beta-adrenergic receptor antagonist. Beta-adrenergic signaling can regulate cilia length and function. By inhibiting this pathway, Propranolol can indirectly affect BBS5 activity within the cilium. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB431542 is a selective inhibitor of transforming growth factor-beta (TGF-beta) type I receptor ALK5 kinase, ALK4 and ALK7. TGF-beta signaling has been implicated in ciliary function. Inhibiting this pathway can indirectly affect BBS5 function within the cilium. | ||||||
Vismodegib | 879085-55-9 | sc-396759 sc-396759A | 10 mg 25 mg | $82.00 $158.00 | 1 | |
Vismodegib is an inhibitor of the Hedgehog signaling pathway, which is highly dependent on ciliary function. By inhibiting this pathway, Vismodegib can indirectly affect BBS5 activity within the cilium. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $94.00 $208.00 | 19 | |
Cyclopamine is another Hedgehog pathway inhibitor. Like Vismodegib, it can indirectly inhibit BBS5 function by affecting ciliary-dependent Hedgehog signaling. | ||||||
Itraconazole | 84625-61-6 | sc-205724 sc-205724A | 50 mg 100 mg | $78.00 $142.00 | 23 | |
Itraconazole is an antifungal agent in research that also inhibits the Hedgehog pathway. It can indirectly affect BBS5 function by disrupting ciliary-dependent Hedgehog signaling. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule dynamics. As cilia are microtubule-based organelles, this can indirectly affect BBS5 function within the cilium. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine is another microtubule disruptor. By affecting microtubule dynamics, it can indirectly inhibit BBS5 function within the cilium. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and prevents their depolymerization. This can indirectly inhibit BBS5 function by affecting ciliary structure and function. | ||||||