BBS5 Antibody (B-11): sc-515331
- BBS5 Antibody (B-11) is a mouse monoclonal IgG1 κ BBS5 antibody, cited in 6 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 23-46 near the N-terminus of BBS5 of human origin
- BBS5 Antibody (B-11) is recommended for detection of BBS5 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-BBS5 Antibody (B-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-515331 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for BBS5 Antibody (B-11) for WB and IHC(P) applications. These reagents are now offered in bundles with BBS5 Antibody (B-11) (see ordering information below).
BBS5 Antibody (B-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects BBS5 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BBS5 (B-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. BBS5 is crucial for the assembly and function of cilia and basal bodies, which are essential cellular structures involved in signaling pathways and cellular motility. Dysfunction in these structures can lead to a range of disorders, including Bardet-Biedl syndrome (BBS), a complex genetic condition characterized by obesity, photoreceptor degeneration, polydactyly, hypogenitalism, renal abnormalities, and developmental delays. The localization of BBS5 to ciliary basal bodies highlights BBS5′s role in maintaining ciliary integrity and function; mutations or loss of BBS5 can disrupt these processes, potentially leading to severe consequences such as photoreceptor degeneration. The diverse applications of anti-BBS5 antibody (B-11) make this reagent an invaluable tool for researchers studying the molecular mechanisms underlying BBS and related ciliary dysfunctions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
BBS5 Antibody (B-11) References:
- Identification of the gene that, when mutated, causes the human obesity syndrome BBS4. | Mykytyn, K., et al. 2001. Nat Genet. 28: 188-91. PMID: 11381270
- Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene. | Li, JB., et al. 2004. Cell. 117: 541-52. PMID: 15137946
- Antenatal presentation of Bardet-Biedl syndrome may mimic Meckel syndrome. | Karmous-Benailly, H., et al. 2005. Am J Hum Genet. 76: 493-504. PMID: 15666242
- Ocular phenotypes of three genetic variants of Bardet-Biedl syndrome. | Héon, E., et al. 2005. Am J Med Genet A. 132A: 283-7. PMID: 15690372
- Proteomic analysis of isolated chlamydomonas centrioles reveals orthologs of ciliary-disease genes. | Keller, LC., et al. 2005. Curr Biol. 15: 1090-8. PMID: 15964273
- No evidence for triallelic inheritance of MKKS/BBS loci in Amish Mckusick-Kaufman syndrome. | Nakane, T. and Biesecker, LG. 2005. Am J Med Genet A. 138: 32-4. PMID: 16104012
- Comparative genomics and gene expression analysis identifies BBS9, a new Bardet-Biedl syndrome gene. | Nishimura, DY., et al. 2005. Am J Hum Genet. 77: 1021-33. PMID: 16380913
- Defining the human macula transcriptome and candidate retinal disease genes using EyeSAGE. | Bowes Rickman, C., et al. 2006. Invest Ophthalmol Vis Sci. 47: 2305-16. PMID: 16723438
- Temporal expression pattern of Bardet-Biedl syndrome genes in adipogenesis. | Forti, E., et al. 2007. Int J Biochem Cell Biol. 39: 1055-62. PMID: 17379567
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BBS5 Antibody (B-11) | sc-515331 | 200 µg/ml | $322.00 | |||
BBS5 Antibody (B-11): m-IgG Fc BP-HRP Bundle | sc-531341 | 200 µg Ab; 10 µg BP | $361.00 | |||
BBS5 Antibody (B-11): m-IgGκ BP-HRP Bundle | sc-525006 | 200 µg Ab, 40 µg BP | $361.00 | |||
BBS5 Antibody (B-11): m-IgG1 BP-HRP Bundle | sc-544493 | 200 µg Ab; 20 µg BP | $361.00 | |||
BBS5 Antibody (B-11) X | sc-515331 X | 200 µg/0.1 ml | $322.00 | |||
BBS5 Antibody (B-11) AC | sc-515331 AC | 500 µg/ml, 25% agarose | $424.00 | |||
BBS5 Antibody (B-11) HRP | sc-515331 HRP | 200 µg/ml | $322.00 | |||
BBS5 Antibody (B-11) FITC | sc-515331 FITC | 200 µg/ml | $336.00 | |||
BBS5 Antibody (B-11) PE | sc-515331 PE | 200 µg/ml | $349.00 | |||
BBS5 Antibody (B-11) Alexa Fluor® 488 | sc-515331 AF488 | 200 µg/ml | $364.00 | |||
BBS5 Antibody (B-11) Alexa Fluor® 546 | sc-515331 AF546 | 200 µg/ml | $364.00 | |||
BBS5 Antibody (B-11) Alexa Fluor® 594 | sc-515331 AF594 | 200 µg/ml | $364.00 | |||
BBS5 Antibody (B-11) Alexa Fluor® 647 | sc-515331 AF647 | 200 µg/ml | $364.00 | |||
BBS5 Antibody (B-11) Alexa Fluor® 680 | sc-515331 AF680 | 200 µg/ml | $364.00 | |||
BBS5 Antibody (B-11) Alexa Fluor® 790 | sc-515331 AF790 | 200 µg/ml | $364.00 | |||
BBS5 (B-11) Neutralizing Peptide | sc-515331 P | 100 µg/0.5 ml | $69.00 |