BBS2 Activators
BBS2 Activators belong to a specialized category of chemicals that are designed to engage and enhance the activity of the protein BBS2, which is short for Bardet-Biedl Syndrome 2. BBS2 is one of several proteins implicated in the proper functioning of the BBSome complex, a group of proteins that play a critical role in ciliary function and signaling. Cilia are microscopic hair-like structures on the surface of cells that are involved in movement and sensory functions. They are essential for various physiological processes such as photoreceptor function in the eye, olfaction, and developmental signaling. The BBSome complex, with BBS2 as a core constituent, is fundamental for the trafficking of membrane proteins to cilia, thereby affecting the composition of the ciliary membrane and influencing ciliary signal transduction. Activators of BBS2 seek to modulate this protein's activity,influencing the assembly and function of the BBSome complex and the process of ciliary protein trafficking.
The specific action of BBS2 Activators can entail a direct interaction with the BBS2 protein, affecting its stability, its interaction with other BBSome components, or its overall conformation. The study of these activators involves examining their binding affinity, specificity, and the resultant conformational or functional changes induced in BBS2. Such an investigation into the molecular dynamics between BBS2 Activators and the BBS2 protein contributes to a deeper understanding of the BBSome complex's role in ciliary function. As BBS2 and its associated protein complex are involved in critical cellular pathways, these activators are also useful in the exploration of the underlying cellular mechanisms that govern ciliary signaling and the maintenance of cellular homeostasis. Through these interactions, BBS2 Activators serve as important biochemical tools that aid researchers in dissecting the nuances of ciliary biology and the intricate networks of intracellular protein trafficking.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride activates the Wnt signaling pathway, which is known to intersect with ciliary signaling pathways. This activation can lead to the stabilization of cytoplasmic beta-catenin, indirectly supporting the ciliary functions associated with BBS2. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases intracellular cAMP levels, which can enhance the protein kinase A (PKA) activity. PKA is involved in the regulation of ciliary structure and function, thus potentially enhancing the activity of BBS2 in ciliary maintenance. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid influences gene expression and has been implicated in ciliary development and function. It may thereby enhance the functional activity of BBS2 by promoting the assembly and maintenance of cilia. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine can alter autophagic flux, which is important for ciliary function and length. By modulating autophagy, chloroquine could indirectly promote the ciliary functions of BBS2. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, a kinase that negatively regulates ciliogenesis. By inhibiting mTOR, rapamycin can enhance ciliary assembly and function, potentially benefiting the role of BBS2 in cilia. | ||||||
Zoledronic acid, anhydrous | 118072-93-8 | sc-364663 sc-364663A | 25 mg 100 mg | $92.00 $256.00 | 5 | |
Zoledronic acid inhibits farnesyl pyrophosphate synthase, which is involved in the post-translational modification of proteins essential for ciliary function. This inhibition may enhance ciliary-associated BBS2 activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates sirtuin 1 (SIRT1), which has been implicated in the regulation of ciliary length and function. Through SIRT1 activation, resveratrol may indirectly enhance the ciliary functions of BBS2. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide is a form of vitamin B3 that can boost cellular NAD+ levels, thereby supporting sirtuins such as SIRT1 which are involved in ciliary function and could thereby enhance BBS2 activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has been observed to modulate multiple cellular signaling pathways and can influence ciliary length and signaling, potentially supporting the ciliary role of BBS2 in cells. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $29.00 $90.00 $339.00 | 12 | |
Lovastatin inhibits HMG-CoA reductase, influencing the mevalonate pathway which is critical for post-translational modifications like prenylation, necessary for ciliary function, thereby potentially enhancing BBS2 activity. | ||||||