BBS2 Antibody (A-12): sc-365355

BBS2 Antibody (A-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects BBS2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BBS2 Antibody (A-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. BBS2 protein, consisting of 721 amino acids, plays a crucial role in cilia function, which is essential for various cellular processes, including signaling pathways and cellular movement. Cilia dysfunction is implicated in Bardet-Biedl syndrome (BBS), a complex genetic disorder characterized by obesity, photoreceptor degeneration, polydactyly, and renal abnormalities. BBS2 shows evolutionary conservation and expression across multiple tissues, including brain, kidney, adrenal gland, and thyroid gland, highlighting a fundamental role in maintaining cellular homeostasis and function. BBS2 deficiencies can lead to significant health issues, including social interaction defects and infertility, as well as progressive loss of photoreceptors in the retina, underscoring BBS2′s critical nature in both developmental and physiological contexts.

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BBS2 Antibody (A-12) References:

1. Positional cloning of a novel gene on chromosome 16q causing Bardet-Biedl syndrome (BBS2).  |  Nishimura, DY., et al. 2001. Hum Mol Genet. 10: 865-74. PMID: 11285252
2. Identification of a novel Bardet-Biedl syndrome protein, BBS7, that shares structural features with BBS1 and BBS2.  |  Badano, JL., et al. 2003. Am J Hum Genet. 72: 650-8. PMID: 12567324
3. Heterozygous mutations in BBS1, BBS2 and BBS6 have a potential epistatic effect on Bardet-Biedl patients with two mutations at a second BBS locus.  |  Badano, JL., et al. 2003. Hum Mol Genet. 12: 1651-9. PMID: 12837689
4. Bbs2-null mice have neurosensory deficits, a defect in social dominance, and retinopathy associated with mislocalization of rhodopsin.  |  Nishimura, DY., et al. 2004. Proc Natl Acad Sci U S A. 101: 16588-93. PMID: 15539463
5. Clinical evidence of decreased olfaction in Bardet-Biedl syndrome caused by a deletion in the BBS4 gene.  |  Iannaccone, A., et al. 2005. Am J Med Genet A. 132A: 343-6. PMID: 15654695
6. Ocular phenotypes of three genetic variants of Bardet-Biedl syndrome.  |  Héon, E., et al. 2005. Am J Med Genet A. 132A: 283-7. PMID: 15690372
7. [Update on Bardet-Biedl syndrome].  |  Dollfus, H., et al. 2005. J Fr Ophtalmol. 28: 106-12. PMID: 15767906
8. Testing for triallelism: analysis of six BBS genes in a Bardet-Biedl syndrome family cohort.  |  Hichri, H., et al. 2005. Eur J Hum Genet. 13: 607-16. PMID: 15770229
9. No evidence for triallelic inheritance of MKKS/BBS loci in Amish Mckusick-Kaufman syndrome.  |  Nakane, T. and Biesecker, LG. 2005. Am J Med Genet A. 138: 32-4. PMID: 16104012
10. Translational readthrough of ciliopathy genes BBS2 and ALMS1 restores protein, ciliogenesis and function in patient fibroblasts.  |  Eintracht, J., et al. 2021. EBioMedicine. 70: 103515. PMID: 34365092
11. The role of BBS2 in regulating adipogenesis and the association of its sequence variants with meat quality in Qinchuan cattle.  |  Long, F., et al. 2022. Genomics. 114: 110416. PMID: 35718089
12. Novel multi-allelic variants, two BBS2 and one PKD1 variant, of renal ciliopathies: A case report and literature review.  |  Zhong, F., et al. 2023. Eur J Med Genet. 66: 104753. PMID: 37003573

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BBS2 Antibody (A-12) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-BBS2 Antibody (A-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

BBS2 Antibody (A-12) Specifications

Alternate Product Name: BBS2

Product Clone Name: A-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 55-300

Epitope Target: BBS2

Epitope Species: human

Product Reactivity/Detection: BBS2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for BBS2 Antibody (A-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin