BAT2D1 Activators
BAT2D1 Activators are a collection of chemical entities that are known to enhance the activity of BAT2D1 through various cellular signaling mechanisms. Forskolin and 8-Br-cAMP raise intracellular cAMP levels, leading to the activation of cAMP-dependent protein kinase A (PKA), which may then phosphorylate BAT2D1 or associated proteins, thereby enhancing BAT2D1 activity if it is cAMP-responsive. IBMX contributes to this enhancement by preventing cAMP degradation, potentially resulting in prolonged or intensified activation of BAT2D1. PMA, through the activation of protein kinase C (PKC), and Ionomycin, by increasing intracellular calcium levels, could lead to the phosphorylation or conformational changes in BAT2D1 or its interacting partners, if BAT2D1 activity is modulated by PKC or calcium-dependent pathways.
Furthermore, EGCG serves to dampen the activity of competing kinases, potentially shifting the cellular signaling balance in favor of BAT2D1 activation, while LY294002 and U0126, which inhibit PI3K and MEK respectively, might indirectly enhance BAT2D1 activity by affecting downstream components of signaling pathways that regulate BAT2D1. SB203580 and A23187, as inhibitors of p38 MAPK and calcium ionophores respectively, could similarly promote BAT2D1 activity by altering signaling dynamics or calcium-dependent processes. Thapsigargin, through SERCA inhibition, leads to increased intracellular calcium levels that could activate BAT2D1 if it is calcium-responsive. Lastly, Isoproterenol stimulates beta-adrenergic receptors, leading to enhanced cAMP production, which may influence BAT2D1 activity through cAMP-dependent signaling pathways. Collectively, these compounds act through distinct yet potentially convergent pathways to amplify the functional activity of BAT2D1.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, increasing intracellular cAMP levels, which could enhance the activity of BAT2D1 if it is cAMP-responsive, by activating PKA that may phosphorylate BAT2D1 or related regulatory proteins. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
8-Br-cAMP is a cell-permeable cAMP analog that activates cAMP-dependent pathways, potentially enhancing BAT2D1 activity if BAT2D1 is part of or regulated by these pathways. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, which prevents the breakdown of cAMP and cGMP, possibly leading to an indirect enhancement of BAT2D1 activity via elevated cAMP or cGMP levels. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), which could lead to the enhanced activity of BAT2D1 through PKC-mediated phosphorylation events if BAT2D1 is regulated by PKC signaling. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, potentially leading to the activation of BAT2D1 if it is regulated by calcium-dependent signaling pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is known to inhibit certain protein kinases, potentially reducing competitive signaling and leading to the relative enhancement of BAT2D1 activity if BAT2D1 operates in a pathway negatively regulated by these kinases. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor which could lead to the activation of BAT2D1 by affecting downstream signaling pathways, such as the AKT pathway, if BAT2D1 activity is enhanced when PI3K signaling is diminished. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a MEK inhibitor that could indirectly enhance the activity of BAT2D1 by modulating the MAPK/ERK pathway, if BAT2D1 is part of or regulated by this pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor and could potentially enhance BAT2D1 activity by altering the balance of signaling through p38 MAPK-regulated pathways if BAT2D1 is modulated by this pathway. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that can lead to the activation of BAT2D1 by increasing intracellular calcium levels and activating calcium-dependent signaling pathways. | ||||||