BAP29 Inhibitors
BAP29 inhibitors are a class of chemical compounds that target and inhibit the function of B-cell receptor-associated protein 29 (BAP29), a transmembrane protein that plays a significant role in the transport and maturation of certain membrane proteins within the endoplasmic reticulum (ER) and the Golgi apparatus. BAP29 is involved in the quality control mechanisms of the ER, where it assists in the proper folding and assembly of newly synthesized proteins, ensuring that only correctly folded proteins are transported to their final destinations, such as the plasma membrane or other organelles. Inhibitors of BAP29 interfere with this function, potentially disrupting the normal trafficking and maturation of proteins that rely on BAP29 for their transport or quality control.
The inhibition of BAP29 can affect cellular processes that are highly dependent on protein sorting and transport, such as signaling pathways, membrane receptor function, and intercellular communication. By targeting BAP29, inhibitors may block its interaction with specific cargo proteins, preventing their proper folding, stabilization, or movement through the secretory pathway. This can lead to the accumulation of misfolded proteins or a reduction in the availability of functional proteins at the cell surface or within organelles. BAP29 inhibitors are valuable tools for studying the mechanisms of protein trafficking and the role of chaperone proteins like BAP29 in maintaining cellular homeostasis. These inhibitors help to elucidate the underlying processes that govern protein sorting, transport, and degradation, offering insights into the intricate balance of protein regulation within the secretory pathway and beyond.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation in the ER, leading to unfolded protein response (UPR) activation. As BAP29 is an ER protein, tunicamycin's induction of UPR can modulate BAP29 function by inducing an environment of ER stress. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
An ER calcium ATPase inhibitor, Thapsigargin leads to calcium release and UPR activation. This disrupts ER homeostasis and can indirectly modulate the function of ER-resident proteins like BAP29. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Disrupts Golgi apparatus structure and function, impacting ER-Golgi vesicular trafficking. Given BAP29's role in the ER, its function can be indirectly affected by disruptions in protein trafficking. | ||||||
Eeyarestatin I | 412960-54-4 | sc-358130B sc-358130 sc-358130A sc-358130C sc-358130D sc-358130E | 5 mg 10 mg 25 mg 50 mg 100 mg 500 mg | $112.00 $199.00 $347.00 $683.00 $1336.00 $5722.00 | 12 | |
Inhibits ER-associated degradation, affecting ER homeostasis. Given BAP29's residence in the ER, alterations in protein degradation processes can indirectly modulate its function. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
Proteasome inhibitor. While not ER-specific, proteasomal degradation plays a role in handling misfolded proteins, particularly during ER stress. By inhibiting the proteasome, MG132 can influence the cellular environment in which BAP29 operates. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Increases intracellular calcium levels, which can disturb ER calcium balance. As an ER protein, BAP29 might be modulated by changes in calcium homeostasis. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
Inhibits IP3 receptors, decreasing ER calcium release. As BAP29 operates within the ER, altered calcium dynamics can have indirect effects on its function. | ||||||
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $33.00 $102.00 | 87 | |
Inhibits dephosphorylation of eIF2α, a key player in UPR. By modulating UPR activity, Salubrinal can create an ER environment that potentially influences BAP29 activity. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $173.00 $612.00 | 3 | |
An inhibitor of ER calcium ATPase, leading to altered calcium dynamics within the ER. This change can indirectly affect ER-resident proteins like BAP29. | ||||||
ISRIB | 1597403-47-8 | sc-488404 | 10 mg | $300.00 | 1 | |
Modulates the integrated stress response (ISR), influencing ER stress responses. Given the ISR's role in responding to ER stress, ISRIB can indirectly modulate the environment in which BAP29 functions. | ||||||