BAP29 Antibody (W352): sc-101213

BAP29 Antibody (W352) is a mouse monoclonal IgG2a kappa light chain antibody that detects BAP29 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-BAP29 antibody (W352) is available as the non-conjugated format. BAP29, also known as BCR-associated protein 29 or BCAP29, is a multi-pass membrane protein that localizes to the endoplasmic reticulum (ER) and is a member of the BCAP29/BCAP31 family of proteins. BAP29 is crucial for maintaining the retention of membrane immunoglobulin D (IgD) molecules within the ER, which is essential for proper B cell development and function. BAP29 is predominantly expressed in the brain and testis, highlighting potential roles in neurobiology and reproductive health. Structurally, BAP29 features a hydrophobic N-terminus, three transmembrane domains, a coiled-coil region, and a C-terminal double-lysine motif implicated in vesicular transport. BAP29 can exist as a homodimer or form heterodimers with BAP31, and the BAP29/BAP31 complex is vital for the trafficking of major histocompatibility complex (MHC) class I molecules, facilitating transport from the ER to the Golgi apparatus. This complex is essential for the immune response, ensuring proper presentation of antigens to T cells, thereby playing a significant role in adaptive immunity.

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BAP29 Antibody (W352) References:

1. The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum.  |  Breckenridge, DG., et al. 2002. Proc Natl Acad Sci U S A. 99: 4331-6. PMID: 11917123
2. A high-molecular-weight complex of membrane proteins BAP29/BAP31 is involved in the retention of membrane-bound IgD in the endoplasmic reticulum.  |  Schamel, WW., et al. 2003. Proc Natl Acad Sci U S A. 100: 9861-6. PMID: 12886015
3. Bap29/31 influences the intracellular traffic of MHC class I molecules.  |  Paquet, ME., et al. 2004. J Immunol. 172: 7548-55. PMID: 15187134
4. BAP31 is involved in the retention of cytochrome P450 2C2 in the endoplasmic reticulum.  |  Szczesna-Skorupa, E. and Kemper, B. 2006. J Biol Chem. 281: 4142-8. PMID: 16332681
5. Assembly of MHC class I molecules within the endoplasmic reticulum.  |  Zhang, Y. and Williams, DB. 2006. Immunol Res. 35: 151-62. PMID: 17003517
6. Bap31 enhances the endoplasmic reticulum export and quality control of human class I MHC molecules.  |  Ladasky, JJ., et al. 2006. J Immunol. 177: 6172-81. PMID: 17056546
7. Bap29varP, a variant of Bap29, influences the cell surface expression of the human P-glycoprotein.  |  Rao, PS., et al. 2008. Int J Oncol. 32: 135-44. PMID: 18097552
8. Two new proteins preferentially associated with membrane immunoglobulin D.  |  Kim, KM., et al. 1994. EMBO J. 13: 3793-800. PMID: 8070407
9. The specificity of association of the IgD molecule with the accessory proteins BAP31/BAP29 lies in the IgD transmembrane sequence.  |  Adachi, T., et al. 1996. EMBO J. 15: 1534-41. PMID: 8612576

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BAP29 Antibody (W352) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-BAP29 Antibody (W352) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

BAP29 Antibody (W352) Specifications

Alternate Product Name: BAP29

Product Clone Name: W352

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 125-241

Epitope Target: BAP29

Epitope Species: human

Product Reactivity/Detection: BAP29

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for BAP29 Antibody (W352): N/A