ATHL1 Inhibitors
ATHL1 inhibitors are chemicals that exert their effects through various mechanisms within the purine metabolic pathway, each leading to an indirect inhibition of ATHL1 activity. Allopurinol and Febuxostat are both xanthine oxidase inhibitors that would lead to the accumulation of purine metabolites, which can trigger feedback inhibition of ATHL1 by increasing the levels of substrates and intermediates that ATHL1 acts upon. Methotrexate and Sulfasalazine both inhibit the synthesis of purine and pyrimidine nucleotides; the resultant decrease in the availability of these molecules can lead to the indirect inhibition of ATHL1 due to a lack of substrates necessary for its action.
Mycophenolic acid, Ribavirin, Tiazofurin, and MIZORIBINE act as inosine monophosphate dehydrogenase inhibitors, which results in reduced guanosine nucleotide production. The consequent substrate depletion for ATHL1's purine-related functions can indirectly diminish its activity. Purine analogs like 6-Mercaptopurine, 6-Thioguanine, and Mercaptopurine Riboside mimic natural substrates of ATHL1 and can competitively inhibit the enzyme, leading to a decrease in its function. Azathioprine, a prodrug for 6-Mercaptopurine, similarly inhibits purine synthesis upon metabolism and thereby potentially reduces ATHL1 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Allopurinol | 315-30-0 | sc-207272 | 25 g | $131.00 | ||
Allopurinol is a xanthine oxidase inhibitor that reduces the production of uric acid. ATHL1 is involved in purine metabolism, and the inhibition of xanthine oxidase by Allopurinol can lead to the accumulation of purine precursors, which could inhibit ATHL1 by feedback inhibition due to excess substrate accumulation. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate is a dihydrofolate reductase inhibitor that leads to reduced purine synthesis. Since ATHL1 is related to purine metabolism, the decrease in purine synthesis can decrease the substrates available for ATHL1, indirectly inhibiting its activity. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $69.00 $266.00 | 8 | |
Mycophenolic acid is an inosine monophosphate dehydrogenase inhibitor that depletes guanosine nucleotides. ATHL1, being associated with nucleotide processes, may be inhibited due to the reduced availability of its guanosine substrates. | ||||||
Ribavirin | 36791-04-5 | sc-203238 sc-203238A sc-203238B | 10 mg 100 mg 5 g | $63.00 $110.00 $214.00 | 1 | |
Ribavirin is a nucleoside analogue that inhibits inosine monophosphate dehydrogenase, which can decrease the pool of guanine nucleotides. This reduction could lead to inhibition of ATHL1 by reducing the availability of its substrates. | ||||||
6-Mercaptopurine | 50-44-2 | sc-361087 sc-361087A | 50 mg 100 mg | $72.00 $104.00 | ||
6-Mercaptopurine is a purine analogue that inhibits several enzymes in the purine synthesis pathway. By mimicking purine substrates, it can inhibit ATHL1 by directly competing with its natural substrates. | ||||||
6-Thioguanine | 154-42-7 | sc-205587 sc-205587A | 250 mg 500 mg | $42.00 $54.00 | 3 | |
Like 6-Mercaptopurine, 6-Thioguanine is a purine analogue that inhibits purine synthesis enzymes. It could inhibit ATHL1 by competing with the substrates for binding, thus reducing the enzyme's functional activity. | ||||||
Azathioprine | 446-86-6 | sc-210853D sc-210853 sc-210853A sc-210853B sc-210853C | 500 mg 1 g 2 g 5 g 10 g | $203.00 $176.00 $349.00 $505.00 $704.00 | 1 | |
Azathioprine is metabolized into 6-Mercaptopurine in the body, which then inhibits purine synthesis. This inhibition can decrease the function of ATHL1 by reducing the availability of its specific substrates. | ||||||
Febuxostat | 144060-53-7 | sc-207680 | 10 mg | $168.00 | 3 | |
Febuxostat is a selective xanthine oxidase inhibitor and, by reducing uric acid synthesis, can result in an accumulation of upstream purine metabolites. This can lead to feedback inhibition of ATHL1. | ||||||
Tiazofurin | 60084-10-8 | sc-475805 | 5 mg | $449.00 | ||
Tiazofurin is an IMP dehydrogenase inhibitor that can cause a reduction in guanine nucleotide pools. The activity of ATHL1, which is involved in nucleotide metabolism, may be indirectly inhibited due to decreased availability of guanine nucleotides. | ||||||
Mizoribine | 50924-49-7 | sc-359617 sc-359617A | 10 mg 25 mg | $109.00 $228.00 | ||
Mizoribine inhibits inosine monophosphate dehydrogenase, leading to lower guanosine nucleotide levels. Reduced guanosine availability can indirectly inhibit the functional activity of ATHL1. | ||||||