Mizoribine (CAS 50924-49-7)
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Mizoribine is an imidazole nucleoside immunosuppressant agent that was first isolated from the mold Eupenicillium brefeldimium with antibiotic and cytotoxic effects. In a mouse model for IgA nephropathy, Mizoribine was documented to influence the proliferation of B cells and decrease the glomerular IgA load while increasing glomerular expansion. In addition in human B cells the compound has been observed to Inhibit the expression of cyclin A. The immunosuppressive effects of Mizoribine Hydrobromide also effects T cells through suppression of G to S phase transition. In the case of puromycin aminonucleoside nephropathy Mizoribine demonstrated the ability to prevent podocyte injury. The compound has also been documented to induce the differentiation of promyelocytes on a mechansim relying on impaired guanine nucleotide synthesis. It belongs to the class of purine analogues and acts as an immunosuppressant.
Mizoribine (CAS 50924-49-7) References
- Mizoribine and mycophenolate mofetil. | Ishikawa, H. 1999. Curr Med Chem. 6: 575-97. PMID: 10390602
- Mizoribine in the treatment of rheumatoid arthritis and juvenile idiopathic arthritis. | Takei, S. 2002. Pediatr Int. 44: 205-9. PMID: 11896888
- Role of mizoribine in renal transplantation. | Tsuzuki, K. 2002. Pediatr Int. 44: 224-31. PMID: 11896891
- Mizoribine corrects defective nephrin biogenesis by restoring intracellular energy balance. | Nakajo, A., et al. 2007. J Am Soc Nephrol. 18: 2554-64. PMID: 17687078
- Mizoribine suppresses the progression of experimental peritoneal fibrosis in a rat model. | Takahashi, S., et al. 2009. Nephron Exp Nephrol. 112: e59-69. PMID: 19390220
- The immunosuppressive drug mizoribine directly prevents podocyte injury in puromycin aminonucleoside nephrosis. | Takeuchi, S., et al. 2010. Nephron Exp Nephrol. 116: e3-10. PMID: 20502051
- Modelling the effects of inhibitors of guanine nucleotide synthesis: implications for studies of cellular differentiation pathways. | Thomas, GM. 2010. Biochem Soc Trans. 38: 1314-8. PMID: 20863305
- The argument for the use of mizoribine in renal transplantation: a meta-analysis and systemic review. | Zhang, X., et al. 2013. Transpl Immunol. 28: 106-11. PMID: 23313278
- Effect of mizoribine pulse therapy in adult membranous nephropathy. | Wang, X., et al. 2021. Int Urol Nephrol. 53: 725-731. PMID: 33159256
- The Efficacy and Safety of Mizoribine versus Mycophenolate Mofetil for the Treatment of Renal Transplantation: A Systematic Review and Meta-Analysis. | Chen, J., et al. 2022. Comput Intell Neurosci. 2022: 5717068. PMID: 35909831
- Mizoribine halts kidney fibrosis in childhood IgA nephropathy: association with modulation of M2-type macrophages. | Ikezumi, Y., et al. 2023. Pediatr Nephrol. 38: 1831-1842. PMID: 36357635
- Mizoribine combined with steroids and dietary sodium restriction on the treatment of primary membranous nephropathy: a prospective study. | Wang, X., et al. 2023. Clin Exp Nephrol. 27: 211-217. PMID: 36574107
- Inhibition of expression of cyclin A in human B cells by an immunosuppressant mizoribine. | Hirohata, S. and Yanagida, T. 1995. J Immunol. 155: 5175-83. PMID: 7594527
- GTP depletion induced by IMP dehydrogenase inhibitors blocks RNA-primed DNA synthesis. | Catapano, CV., et al. 1995. Mol Pharmacol. 47: 948-55. PMID: 7746281
- Effect of mizoribine on glomerulonephritis of early-stage IgA nephropathy in ddY mice. | Shimizu, M., et al. 1998. Nephron. 79: 67-72. PMID: 9609465
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mizoribine, 10 mg | sc-359617 | 10 mg | $107.00 | |||
Mizoribine, 25 mg | sc-359617A | 25 mg | $224.00 |