Date published: 2025-11-25

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Atg16L2 Inhibitors

Atg16L2 inhibitors constitute a specialized class of chemical compounds that have gained prominence in the field of molecular biology and autophagy research. Atg16L2, or Autophagy-Related 16-Like 2, is a protein involved in the regulation of autophagy, a cellular process responsible for degrading and recycling cellular components to maintain cellular homeostasis and respond to various stress conditions. The term Atg16L2 inhibitors refers to a group of molecules meticulously designed to selectively target and modulate the activity of Atg16L2. These inhibitors serve as invaluable tools in laboratory investigations, enabling researchers to explore the intricate molecular functions and cellular processes associated with Atg16L2.

Atg16L2 inhibitors typically function by interfering with the role of Atg16L2 in the initiation and formation of autophagic structures, such as autophagosomes, which are essential for the sequestration and degradation of cellular cargo. This interference can disrupt the normal process of autophagy, impacting various aspects of cellular quality control, stress response, and adaptation. Researchers employ Atg16L2 inhibitors to gain insights into the physiological roles and molecular interactions of Atg16L2 within cells, aiming to advance our understanding of the fundamental mechanisms involved in autophagy regulation. Through the study of Atg16L2 inhibitors, scientists seek to unravel the complexities of cellular self-cleaning processes, cellular responses to stress, and the broader field of cell biology, contributing to our knowledge of how cells maintain their health and adapt to changing environmental conditions.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Spautin-1

1262888-28-7sc-507306
10 mg
$165.00
(0)

Spautin-1 promotes the degradation of Vps34 PI3 kinase complexes, potentially disrupting autophagy and indirectly affecting Atg16L2 expression or stability.

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$66.00
$219.00
$417.00
97
(3)

Wortmannin is a PI3K inhibitor; by inhibiting Vps34, it may dampen autophagy initiation, potentially altering Atg16L2 expression as part of the cellular response.

Autophagy Inhibitor, 3-MA

5142-23-4sc-205596
sc-205596A
50 mg
500 mg
$56.00
$256.00
113
(3)

3-Methyladenine (3-MA) inhibits Class III PI3K, which is crucial for autophagy initiation, possibly leading to reduced Atg16L2 expression associated with autophagy machinery.

Chloroquine

54-05-7sc-507304
250 mg
$68.00
2
(0)

Chloroquine disrupts autophagosome-lysosome fusion; while not a direct inhibitor of Atg16L2 expression, it influences autophagy pathways where Atg16L2 is integral.

hydroxychloroquine

118-42-3sc-507426
5 g
$56.00
1
(0)

Hydroxychloroquine, similar to Chloroquine, affects autophagosome function and may indirectly modify the expression or stability of autophagy-related proteins like Atg16L2.

Bafilomycin A1

88899-55-2sc-201550
sc-201550A
sc-201550B
sc-201550C
100 µg
1 mg
5 mg
10 mg
$96.00
$250.00
$750.00
$1428.00
280
(6)

Bafilomycin A1 inhibits the vacuolar H+ ATPase and impairs autophagosome-lysosome fusion which could influence Atg16L2 turnover.

SAR405

1523406-39-4sc-507416
1 mg
$125.00
(0)

SAR405 is a specific inhibitor of Vps34, which could disrupt the formation of autophagosomes, potentially reducing the requirement for Atg16L2 activity.

Torin 1

1222998-36-8sc-396760
10 mg
$240.00
7
(1)

Torin 1 targets mTOR, a central regulator of autophagy; inhibition of mTOR can induce autophagy, potentially altering Atg16L2 expression levels in response.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

Although previously mentioned for another protein, LY294002's role in PI3K inhibition could similarly affect Atg16L2 expression through autophagy modulation.

SBI-0206965

1884220-36-3sc-507431
10 mg
$122.00
(0)

SBI-0206965 is an inhibitor of the autophagy kinase ULK1; inhibition of ULK1 activity could impact Atg16L2's role in autophagosome formation.