Atg16 Inhibitors
Atg16 inhibitors belong to a class of chemical compounds that primarily target the autophagy-related protein 16 (Atg16), which plays a pivotal role in the autophagy process within cells. Autophagy is a highly regulated cellular mechanism responsible for the degradation and recycling of cellular components, including damaged organelles and protein aggregates, to maintain cellular homeostasis. Atg16 is a critical component of the autophagy machinery, as it forms a complex with other proteins, such as Atg5 and Atg12, to facilitate the elongation of the isolation membrane, also known as the phagophore, into a double-membraned vesicle called the autophagosome. The autophagosome ultimately engulfs cellular cargo and delivers it to lysosomes for degradation and recycling. Inhibition of Atg16 can disrupt this process, leading to alterations in cellular homeostasis.
Atg16 inhibitors, through their interaction with Atg16, can hinder the proper formation and function of autophagosomes. This disruption in autophagic processes can have various consequences on cellular functions, including the accumulation of damaged organelles and proteins, impaired quality control mechanisms, and potentially impacting cell survival and differentiation. Research into Atg16 inhibitors is of significant interest in the field of cell biology, as it helps elucidate the intricacies of autophagy regulation and its role in various cellular processes.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $65.00 $261.00 | 113 | |
This compound is a known autophagy inhibitor that can inhibit the early stages of the autophagic process, which may indirectly affect Atg16 function, as Atg16 is involved in the autophagosome formation. | ||||||
Spautin-1 | 1262888-28-7 | sc-507306 | 10 mg | $168.00 | ||
Spautin-1 promotes the degradation of Vps34 PI3 kinase complexes, which are required for autophagy initiation. Atg16 operates downstream of these complexes, thus its activity can be indirectly inhibited. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent inhibitor of phosphoinositide 3-kinases (PI3K), which can inhibit autophagy upstream of Atg16 involvement in autophagosome formation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor, which may indirectly inhibit Atg16 by disrupting the pathways necessary for the initiation of autophagy. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
This compound inhibits the vacuolar type H+-ATPase (V-ATPase), which can lead to inhibition of autophagosome-lysosome fusion, thereby indirectly affecting Atg16's role in autophagy. | ||||||
hydroxychloroquine | 118-42-3 | sc-507426 | 5 g | $57.00 | 1 | |
Similar to chloroquine, hydroxychloroquine raises lysosomal pH and can inhibit autophagosome-lysosome fusion, which is a process Atg16 contributes to. | ||||||
Saracatinib | 379231-04-6 | sc-364607 sc-364607A | 10 mg 200 mg | $115.00 $1056.00 | 7 | |
Saracatinib is an Src kinase inhibitor, and while not a direct inhibitor of Atg16, it may alter signaling pathways that affect autophagy, and consequently, Atg16 activity. | ||||||
Concanamycin A | 80890-47-7 | sc-202111 sc-202111A sc-202111B sc-202111C | 50 µg 200 µg 1 mg 5 mg | $66.00 $167.00 $673.00 $2601.00 | 109 | |
This compound is a V-ATPase inhibitor like bafilomycin A1 and can prevent the acidification of lysosomes, thereby affecting Atg16 function in autophagosome maturation. | ||||||
Lys05 | 1391426-24-6 | sc-507532 | 5 mg | $140.00 | ||
Lys05 is a dimeric chloroquine that can more potently disrupt lysosome function, affecting Atg16's role in autophagy. | ||||||
MHY1485 | 326914-06-1 | sc-507522 | 10 mg | $140.00 | ||
MHY1485 is an mTOR activator, which can suppress autophagy induction and thus indirectly affect Atg16 function in autophagosome formation. | ||||||