ASPHD2 Activators
Chemical activators of ASPHD2 are not necessarily direct but can influence a variety of cellular and biochemical pathways that potentially elevate the activity or expression of ASPHD2. The chemicals listed can modulate epigenetic marks, gene transcription, signal transduction, and cellular stress responses, among other processes. These activators may have a role in influencing the broader regulatory networks within which ASPHD2 functions, albeit in an indirect manner. Their actions are varied, ranging from the alteration of gene expression through epigenetic changes, such as with Sodium Butyrate and 5-Azacytidine, to the modulation of signal transduction pathways as seen with Forskolin and Metformin.
The described class of ASPHD2 activators encompasses a spectrum of compounds that impact cellular homeostasis, energy balance, and regulatory mechanisms governing protein function. While the activation of ASPHD2 by these compounds involves indirect mechanisms, the breadth of their action reflects the multifaceted nature of cellular regulation. For instance, agents like Resveratrol and Pioglitazone alter the activity of enzymes and transcription factors, which could result in an upregulation of ASPHD2 expression or activity. Oxidative stress inducers like Hydrogen Peroxide may initiate a cascade of cellular responses that include the modification of ASPHD2 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor that can lead to the hyperacetylation of histones, thereby affecting gene expression. Enhanced transcription of genes could increase the expression of ASPHD2 if it is among the genes upregulated by such global chromatin modifications. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor that can cause hypomethylation of DNA and potentially activate silenced genes. By this mechanism, if the ASPHD2 gene is epigenetically silenced, its expression could be upregulated. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid is a metabolite of vitamin A that can regulate gene expression through its role as a ligand for nuclear receptors. If ASPHD2 is among the genes responsive to retinoic acid signaling, this compound could upregulate its expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels and activation of protein kinase A (PKA). PKA can phosphorylate various proteins and transcription factors, potentially increasing ASPHD2 expression if it is responsive to cAMP-mediated signaling pathways. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
Metformin activates AMP-activated protein kinase (AMPK), a sensor of cellular energy status. Activation of AMPK leads to various downstream effects that could include modulation of protein expression, possibly affecting ASPHD2 if it is part of AMPK-regulated pathways. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenolic compound that can activate sirtuins, a class of protein deacetylases. Through this activation, resveratrol may influence gene expression and protein function, potentially including ASPHD2. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
Pioglitazone is a PPAR-gamma agonist that modulates transcription of insulin-sensitive genes. If ASPHD2 expression or activity is related to insulin signaling, this chemical could have an activating effect on it. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Hydrogen peroxide serves as a signaling molecule that can induce oxidative stress response pathways. If ASPHD2 has a role in responding to oxidative stress or is regulated by redox-sensitive transcription factors, this compound may affect its activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a catechin found in green tea with various biological activities, including the modulation of signaling pathways and gene expression. Its potential effect on ASPHD2 activity would be through these broad effects on cellular signaling. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a component of turmeric with anti-inflammatory properties that may modulate transcription factors and enzymes involved in inflammation. If ASPHD2 is regulated by inflammatory pathways, curcumin may indirectly increase its activity. | ||||||