ASB-3 Inhibitors
ASB-3 inhibitors work by influencing the ubiquitin-proteasome system and related protein degradation pathways. This is because ASB-3 is an E3 ubiquitin ligase, and its main function is to mark proteins for degradation via the proteasome. Bortezomib, MG-132, Epoxomicin, and Lactacystin are all proteasome inhibitors. They inhibit the proteasome, preventing the degradation of ubiquitinated proteins and thereby disruptingthe balance that ASB-3 helps to maintain through marking proteins for destruction. The result is an accumulation of proteins that were marked by ASB-3, leading to its functional inhibition.
Other compounds disrupt the ubiquitin-proteasome system in different ways. PYR-41, for instance, inhibits the initiation of ubiquitination by targeting ubiquitin-activating enzyme E1, preventing ASB-3 from marking proteins for degradation. Compounds like MLN4924 target the NEDD8 pathway, which is involved in the modification of cullins, a crucial component of E3 ubiquitin ligases like ASB-3. Other inhibitors, such as PR-619, target the deubiquitination process, which is essential for the degradation of proteins marked by ASB-3. Eeyarestatin I targets the ER-associated degradation pathway, which, when inhibited, disrupts the balance between protein synthesis and degradation that ASB-3 is involved in. Chloroquine and Leupeptin inhibit lysosomal function and protease activity, respectively, both of which are involved in the degradation of proteins marked by ASB-3. Auranofin induces oxidative stress, which can directly affect the function of many proteins, including ASB-3.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib is a proteasome inhibitor that inhibits the degradation of proteins marked for destruction by ubiquitin. ASB-3, as an E3 ubiquitin ligase, marks proteins for degradation. Bortezomib's action disrupts the balance of protein turnover regulated by ASB-3 by inhibiting the degradation of proteins that ASB-3 has marked. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132, like Bortezomib, is a proteasome inhibitor. It inhibits the degradation of proteins, disrupting the balance between synthesis and degradation. As ASB-3 is an E3 ubiquitin ligase, the action of MG-132 directly affects its function by disrupting the degradation of proteins marked by ASB-3. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $137.00 $219.00 $449.00 $506.00 | 19 | |
Epoxomicin is a proteasome inhibitor that blocks the degradation of proteins marked by ubiquitination. As an E3 ubiquitin ligase, ASB-3 marks proteins for degradation, thus the action of Epoxomicin can inhibit the function of ASB-3 by disrupting the degradation process. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $286.00 | 1 | |
MLN4924 is a NEDD8-activating enzyme inhibitor. NEDD8 is a ubiquitin-like protein that modifies cullin proteins, which are part of the Cullin-RING E3 ubiquitin ligases that ASB-3 is a member of. By inhibiting NEDD8, MLN4924 can disrupt the function of ASB-3, leading to decreased activity. | ||||||
Ubiquitin E1 Inhibitor, PYR-41 | 418805-02-4 | sc-358737 | 25 mg | $360.00 | 4 | |
PYR-41 is an irreversible inhibitor of ubiquitin-activating enzyme E1. As an E3 ubiquitin ligase, ASB-3 cannot mark proteins for degradation without the initiation of ubiquitination. PYR-41 inhibits the initiation of ubiquitination, indirectly affecting the function of ASB-3. | ||||||
PR 619 | 2645-32-1 | sc-476324 sc-476324A sc-476324B | 1 mg 5 mg 25 mg | $77.00 $188.00 $431.00 | 1 | |
PR-619 is a broad-spectrum deubiquitinase inhibitor. It inhibits the removal of ubiquitin from proteins, disrupting the balance between ubiquitination and deubiquitination. This can inhibit ASB-3's function, as the removal of ubiquitin is a necessary step in the degradation of proteins marked by ASB-3. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
Lactacystin is a proteasome inhibitor that inhibits protein degradation. As ASB-3 is an E3 ubiquitin ligase that marks proteins for degradation, the action of Lactacystin can disrupt the function of ASB-3. | ||||||
Chloroquine Sulphate | 132-73-0 | sc-337629 | 25 mg | $224.00 | 2 | |
Chloroquine disrupts lysosomal function by altering the intracellular pH. This inhibits the degradation of proteins marked for destruction by ASB-3 as lysosomes are involved in the degradation of these proteins. | ||||||
Eeyarestatin I | 412960-54-4 | sc-358130B sc-358130 sc-358130A sc-358130C sc-358130D sc-358130E | 5 mg 10 mg 25 mg 50 mg 100 mg 500 mg | $114.00 $203.00 $354.00 $697.00 $1363.00 $5836.00 | 12 | |
Eeyarestatin I is an inhibitor of the endoplasmic reticulum-associated degradation (ERAD) pathway. By inhibiting ERAD, Eeyarestatin I can disrupt the balance between protein synthesis and degradation, potentially inhibiting the function of ASB-3. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $153.00 $214.00 $4000.00 | 39 | |
Auranofin is a Thioredoxin reductase inhibitor, and this enzyme is vital for maintaining the reduced state of many proteins. Its inhibition can lead to oxidative stress and affect the function of many proteins, including ASB-3. | ||||||