ARHGAP9 Activators
ARHGAP9 Activators are a group of compounds that act by influencing the protein kinase C (PKC) pathway and the adenylate cyclase-cAMP-EPAC-Rap1 pathway. ARHGAP9 is a member of the Rho GTPase activating proteins (GAPs), which are implicated in various biological processes including the regulation of small GTPases such as Rap1. The PKC pathway is one of the pathways known to regulate GAPs. Phorbol 12-myristate 13-acetate (PMA), Bryostatin 1, and DAG are PKC activators that can enhance the functional activity of ARHGAP9 by activating PKC.
The second group of compounds that can activate ARHGAP9 are those that influence the adenylate cyclase-cAMP-EPAC-Rap1 pathway. Adenylate cyclase, the enzyme responsible for converting ATP to cAMP, and phosphodiesterases, the enzymesthat degrades cAMP, play crucial roles in this pathway. Prostaglandin E1 (PGE1), Forskolin, Cloprostenol, Isoproterenol, Iloprost, Terbutaline, and Albuterol are compounds that activate adenylate cyclase, leading to increased cAMP production. This upsurge in cAMP can trigger the activation of EPAC, which is a direct activator of the small GTPase Rap1. ARHGAP9 is known to interact with Rap1 and hence, these compounds can indirectly enhance the functional activity of ARHGAP9 by activating Rap1. On the other hand, IBMX, a non-selective inhibitor of phosphodiesterases, can enhance ARHGAP9 activity by increasing cAMP levels due to the inhibition of its degradation. Lastly, 8-Bromo-cAMP, a cell-permeable cAMP analog, can also activate EPAC and subsequently Rap1, thereby indirectly enhancing the functional activity of ARHGAP9.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a protein kinase C (PKC) activator. ARHGAP9, as a GTPase activating protein (GAP), is known to be regulated by PKC. Thus, by activating PKC, PMA can enhance the functional activity of ARHGAP9. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $240.00 | 9 | |
Bryostatin 1 is another PKC activator. It can enhance ARHGAP9 activity by activating PKC, which is known to regulate GAPs like ARHGAP9. | ||||||
1,2-Dioctanoyl-sn-glycerol | 60514-48-9 | sc-202397 sc-202397A | 10 mg 50 mg | $46.00 $249.00 | 2 | |
DAG is a PKC activator that can bind and activate PKC, leading to the enhanced activity of ARHGAP9, as GAPs like ARHGAP9 are regulated by PKC. | ||||||
PGE1 (Prostaglandin E1) | 745-65-3 | sc-201223 sc-201223A | 1 mg 10 mg | $30.00 $142.00 | 16 | |
PGE1 activates adenylate cyclase, which increases cAMP levels. This can lead to the activation of EPAC, a direct activator of Rap1, a small GTPase. ARHGAP9 is known to interact with Rap1, and thus PGE1 indirectly activates ARHGAP9. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels, which can activate EPAC and subsequently Rap1. As ARHGAP9 is known to interact with Rap1, forskolin indirectly enhances the functional activity of ARHGAP9. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog used to activate cAMP-dependent pathways. It can activate EPAC and subsequently Rap1, a known interactor of ARHGAP9, therefore indirectly enhancing ARHGAP9 activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, which break down cAMP. By inhibiting these enzymes, IBMX increases the level of cAMP, which can subsequently activate EPAC and Rap1, indirectly enhancing ARHGAP9 activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a non-selective beta-adrenergic agonist that activates adenylate cyclase, leading to increased cAMP levels. This can activate EPAC and subsequently Rap1, indirectly enhancing ARHGAP9 activity. | ||||||
Iloprost | 78919-13-8 | sc-205349 sc-205349A | 500 µg 1 mg | $155.00 $269.00 | ||
Iloprost is a potent and stable analog of prostacyclin that can activate adenylate cyclase, increasing cAMP levels, which can activate EPAC and subsequently Rap1, indirectly enhancing ARHGAP9 activity. | ||||||
Terbutaline Hemisulfate | 23031-32-5 | sc-204911 sc-204911A | 1 g 5 g | $90.00 $371.00 | 2 | |
Terbutaline is a beta2-adrenergic agonist that activates adenylate cyclase, leading to increased cAMP levels. This can activate EPAC and subsequently Rap1, indirectly enhancing ARHGAP9 activity. | ||||||