Annexin III Inhibitors
Annexin III, also known as Annexin A3, is a member of the annexin family of calcium-dependent phospholipid-binding proteins, which play a crucial role in the regulation of cellular processes such as membrane trafficking, inflammation, and cell proliferation. Characterized by its ability to bind to phospholipids in a calcium-dependent manner, Annexin III is implicated in various cellular functions, including the mediation of membrane-cytoskeleton interactions, involvement in the endocytic pathways, and regulation of phospholipase A2 activities. This protein is not only significant for its role in intracellular signaling pathways but also for its involvement in the extracellular matrix and cellular response to stress. Its expression and activity are critical for maintaining cellular homeostasis and responding to physiological changes, making the regulation of Annexin III an important aspect of cellular function and signaling.
The inhibition of Annexin III involves complex mechanisms that can impact its expression levels, interaction with phospholipids, and subsequent cellular functions. Inhibition can occur through various pathways, including the downregulation of expression via genetic mechanisms or the interference with its calcium-dependent phospholipid binding. Such inhibition can alter the normal physiological roles of Annexin III, affecting processes like membrane repair, cell proliferation, and apoptosis. On a molecular level, inhibitors of Annexin III may act by disrupting the protein's ability to bind to specific phospholipid sites, thereby inhibiting its function in membrane-related processes or its role in intracellular signaling pathways. Additionally, the modulation of calcium levels within the cell can indirectly influence the activity of Annexin III, as its interactions with phospholipids are heavily dependent on the presence of calcium ions. By understanding the mechanisms of inhibition, researchers can elucidate the diverse roles of Annexin III in cellular processes and its potential impact on cellular homeostasis and response to external stimuli.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a covalent inhibitor of phosphoinositide 3-kinases (PI3Ks), which are part of the signaling pathway where Annexin III is involved. It can disrupt the pathway, thereby affecting Annexin III indirectly. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is another PI3K inhibitor. It can interfere with the PI3K/Akt pathway, thereby indirectly affecting Annexin III. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid that can inhibit PI3K, a pathway where Annexin III is involved. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor. It can interrupt tyrosine kinase-mediated signaling pathways, thereby indirectly affecting Annexin III. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a potent and selective inhibitor of MEK. It can interfere with the MEK/ERK pathway, affecting Annexin III indirectly. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAPK. As Annexin III is involved in the MAPK signaling pathway, this can impact its activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a potent, selective, and reversible inhibitor of JNK MAPK. It can interfere with the JNK pathway, affecting Annexin III indirectly. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $104.00 $141.00 | 14 | |
Triciribine is an inhibitor of AKT, a protein kinase B, that is part of the pathway where Annexin III is involved. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin is a potent P450 inhibitor for CYP2C9, which can impact multiple signaling pathways, and thereby indirectly affect Annexin III. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an inhibitor of mTOR, a serine/threonine protein kinase, which is involved in the same pathway as Annexin III. | ||||||