Ankyrin-1 Inhibitors
Ankyrin-1 inhibitors belong to a specific chemical class of compounds designed to modulate the activity of the Ankyrin-1 protein. Ankyrin-1 is a cytoskeletal protein that plays a critical role in the organization and stability of the cell membrane. It is involved in various cellular processes, including cell adhesion, ion channel regulation, and cell membrane organization. Inhibitors of Ankyrin-1 are designed to selectively target this protein and interfere with its function, affecting its role in cell membrane integrity and cellular processes.
The mechanism of action of these inhibitors typically involves direct interaction with Ankyrin-1 or its associated binding partners, disrupting its function in maintaining the structural integrity of the cell membrane or modulating its interactions with other cellular components. Researchers use Ankyrin-1 inhibitors to gain insights into the specific functions and molecular interactions involving this protein in different cellular contexts. Understanding the structural characteristics and mechanisms of Ankyrin-1 inhibitors is crucial for advancing knowledge in this area and may have broader implications for future research in cell biology and related fields.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A may downregulate Ankyrin 1 by impeding histone deacetylase activity, resulting in the hyperacetylation of histone proteins at the ANK1 gene locus and subsequent transcriptional repression. | ||||||
2,3-Butanedione 2-Monoxime | 57-71-6 | sc-203774 sc-203774A sc-203774B sc-203774C | 25 g 100 g 250 g 500 g | $41.00 $76.00 $158.00 $280.00 | ||
2,3-butanedione monoxime is a chemical compound that has been reported to inhibit Ankyrin-1 function, affecting its role in cell membrane organization. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By inhibiting DNA methyltransferase, 5-Azacytidine could decrease Ankyrin 1 levels by promoting the demethylation of the ANK1 gene promoter, which may silence gene expression. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $179.00 $307.00 $455.00 $924.00 $1689.00 | 7 | |
Blebbistatin is a small molecule inhibitor primarily known for its effects on myosin, but it has also been found to affect Ankyrin-1 and its association with the cell membrane. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid may downregulate Ankyrin 1 by binding to its nuclear receptors, which can alter the transcription of genes that contribute to cell differentiation processes where Ankyrin 1 is less expressed. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate could decrease Ankyrin 1 expression through histone deacetylase inhibition, enhancing the acetylation of histones near the ANK1 gene and repressing its transcription. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate may indirectly reduce Ankyrin 1 levels by limiting nucleotide synthesis, thereby hampering the overall process of DNA replication and gene expression, including that of ANK1. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
By inhibiting ribonucleotide reductase, Hydroxyurea could lead to a decrease in Ankyrin 1 by reducing the pool of nucleotides necessary for DNA synthesis, thereby lowering transcription rates. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1 is a small molecule known for its bromodomain inhibition, but it has also been reported to affect Ankyrin-1 and its role in cell adhesion. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
5-Aza-2′-Deoxycytidine could lead to a reduction in Ankyrin 1 expression by hypomethylating DNA sequences at the ANK1 gene promoter, which may trigger gene silencing mechanisms. | ||||||