Ankyrin-1 Inhibitors
Ankyrin-1 inhibitors belong to a specific chemical class of compounds designed to modulate the activity of the Ankyrin-1 protein. Ankyrin-1 is a cytoskeletal protein that plays a critical role in the organization and stability of the cell membrane. It is involved in various cellular processes, including cell adhesion, ion channel regulation, and cell membrane organization. Inhibitors of Ankyrin-1 are designed to selectively target this protein and interfere with its function, affecting its role in cell membrane integrity and cellular processes.
The mechanism of action of these inhibitors typically involves direct interaction with Ankyrin-1 or its associated binding partners, disrupting its function in maintaining the structural integrity of the cell membrane or modulating its interactions with other cellular components. Researchers use Ankyrin-1 inhibitors to gain insights into the specific functions and molecular interactions involving this protein in different cellular contexts. Understanding the structural characteristics and mechanisms of Ankyrin-1 inhibitors is crucial for advancing knowledge in this area and may have broader implications for future research in cell biology and related fields.
SEE ALSO...
Items 11 to 17 of 17 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine could inhibit Ankyrin 1 synthesis by intercalating into DNA, disrupting the transcription of multiple genes, including potentially the ANK1 gene, thus reducing its expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin may inhibit Ankyrin 1 synthesis by suppressing mTOR signaling, which is crucial for protein synthesis and may result in a generalized decrease in protein expression. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid may downregulate Ankyrin 1 expression by inhibiting histone deacetylase, leading to an open chromatin structure at the ANK1 gene locus that represses transcription. | ||||||
GW4869 | 6823-69-4 | sc-218578 sc-218578A | 5 mg 25 mg | $199.00 $599.00 | 24 | |
GW4869 is a small molecule inhibitor primarily known for its effects on exosome biogenesis, but it has also been found to affect Ankyrin-1 and its association with the cell membrane. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid could reduce Ankyrin 1 levels by inhibiting histone deacetylases, causing increased acetylation of histone proteins and transcriptional inhibition of the ANK1 gene. | ||||||
Ulixertinib | 869886-67-9 | sc-507296 | 10 mg | $176.00 | ||
Ulixertinib is a small molecule inhibitor of ERK1/2 kinases, and it has been identified as an Ankyrin-1 inhibitor in specific cellular contexts. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol may suppress the expression of Ankyrin 1 by altering the transcriptional machinery, possibly through changes in the ANK1 gene′s promoter accessibility to transcription factors. | ||||||