ANKS6 Activators
ANKS6 Activators are a series of chemically diverse compounds that facilitate the functional enhancement of the ANKS6 protein, primarily through indirect modulation of various signaling cascades and cellular mechanisms. Forskolin and IBMX elevate intracellular cyclic AMP (cAMP) levels, which in turn activate protein kinase A (PKA). PKA-mediated phosphorylation events are crucial for the functional activation of ANKS6, particularly in its role in renal development and the maintenance of ciliary structure and function. Phorbol 12-myristate 13-acetate (PMA) targets protein kinase C (PKC), leading to phosphorylation of proteins that intersect with ANKS6-dependent pathways, thereby enhancing ANKS6's role in nephronophthisis-connected processes. The cAMP analog 8-Br-cAMP similarly activates PKA, reinforcing ANKS6's activity, whereas Genistein, by inhibiting tyrosine kinase activity, may alleviate competitive signaling, thereby indirectly facilitating ANKS6's involvement in renal cellular homeostasis.
In the context of phosphatidylinositol 3-kinase (PI3K) signaling, LY294002 and Wortmannin indirectly serve as ANKS6 activators by inhibiting the PI3K/AKT pathway, which may lead to the upregulation of ANKS6-related functions within renal cellular processes. Sphingosine-1-phosphate, by activating its specific receptors, is posited to enhance ANKS6's role in kidney structure and function through lipid signaling pathways. The ionophore A23187 and the SERCA pump inhibitor Thapsigargin both induce rises in intracellular calcium levels, activating calcium-dependent signaling pathways that are likely to enhance ANKS6 activity, given its association with calcium-regulated processes in renal cells. Additionally, SB203580 and U0126, as inhibitors of p38 MAPK and MEK, respectively, may skew signaling dynamics in favor of pathways that amplify ANKS6's function, further illustrating the intricate network of cellular signaling that these activators tap into to indirectly enhance ANKS6 activity
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin increases intracellular cAMP levels, which enhances the activity of ANKS6 by stimulating cAMP-dependent protein kinase A (PKA). PKA phosphorylation can lead to changes in cellular dynamics that support ANKS6's role in renal development and function. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Isobutylmethylxanthine (IBMX) is a non-selective inhibitor of phosphodiesterases, leading to increased cAMP levels that can indirectly enhance ANKS6 activity via PKA activation and subsequent signaling events related to kidney development. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which can phosphorylate intermediates that support ANKS6-related signaling pathways, potentially enhancing its functional role in nephronophthisis-related pathways. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromoadenosine 3',5'-cyclic monophosphate is a cAMP analog that activates PKA, thus indirectly enhancing ANKS6 activity by influencing cellular processes related to ciliary function and kidney development. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can indirectly enhance ANKS6 activity by altering signaling pathways that intersect with ANKS6's functional role in ciliary processes and cellular homeostasis in the kidney. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can indirectly enhance ANKS6 activity by modulating downstream AKT signaling, which is implicated in cellular processes relevant to ANKS6's function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor that can bolster ANKS6 activity by dampening AKT pathway signaling, thus potentially enhancing signaling mechanisms that ANKS6 is involved in within renal cells. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
This lipid signaling molecule can enhance ANKS6 activity by acting on sphingosine-1-phosphate receptors, which are involved in pathways related to ANKS6's role in kidney structure and function. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium levels, enhancing ANKS6 activity by activating calcium-dependent signaling pathways that are crucial for nephronophthisis-related cellular functions. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor that can indirectly enhance ANKS6 activity by shifting the signaling equilibrium to favor pathways associated with ANKS6's role in renal ciliary function and development. | ||||||