ANKDD1B Activators
Intracellular signaling pathways modulate the activity of ANKDD1B through a variety of mechanisms, primarily involving the phosphorylation state of the protein. Activation of adenylate cyclase by certain compounds leads to an increase in cAMP levels within the cell, which in turn activates protein kinase A (PKA). The activated PKA can then phosphorylate ANKDD1B, resulting in the enhancement of its functional activity. Similarly, the use of phosphodiesterase inhibitors causes an accumulation of cAMP, further promoting PKA activity and potential phosphorylation of ANKDD1B. Analogous to this process, certain cyclic nucleotide analogs are designed to be resistant to degradation, maintaining elevated PKA activity over extended periods and thus, potentially contributing to ANKDD1B activation.
Additionally, other activators operate through distinct pathways that also impinge on the activity of ANKDD1B. For example, compounds that act as ionophores increase intracellular calcium levels, which may activate calcium-dependent protein kinases capable of phosphorylating ANKDD1B. This effect is also seen with inhibitors of protein phosphatases, which prevent the dephosphorylation of proteins, potentially leading to an increased phosphorylated state of ANKDD1B. Alternatively, inhibition of particular kinases can disrupt normal signaling cascades, possibly resulting in compensatory activation of other kinases that would then phosphorylate ANKDD1B. Inhibitionof protein synthesis has also been shown to activate stress-activated protein kinases, which are involved in phosphorylating various substrates and could indirectly lead to the activation of ANKDD1B.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, increasing cAMP levels within the cell. Elevated cAMP can activate PKA, which may phosphorylate ANKDD1B, enhancing its functional activity. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
As a cAMP analog, this compound resists degradation and persistently activates PKA. PKA activation can result in phosphorylation of ANKDD1B, leading to its increased activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, leading to an accumulation of cAMP and activation of PKA. PKA can potentially phosphorylate and activate ANKDD1B. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC) which can modulate signaling pathways that result in the phosphorylation and activation of ANKDD1B. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, potentially activating calcium-dependent protein kinases which may phosphorylate and activate ANKDD1B. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that can elevate intracellular calcium levels, potentially leading to the activation of calcium-dependent kinases that phosphorylate ANKDD1B. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A is an inhibitor of protein phosphatases 1 and 2A, resulting in increased phosphorylation levels within the cell. This may lead to enhanced phosphorylation and activation of ANKDD1B. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
As an inhibitor of protein phosphatases, okadaic acid prevents dephosphorylation, which may result in the accumulation of phosphorylated ANKDD1B, thereby increasing its activity. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
This cAMP analog penetrates cells and resists degradation, leading to sustained PKA activation. PKA may then phosphorylate and contribute to the activation of ANKDD1B. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Can inhibit certain types of protein kinases, altering signaling pathways and potentially leading to compensatory mechanisms that activate kinases which phosphorylate ANKDD1B. | ||||||