Angptl5 Activators
Chemicals categorized as Angptl5 activators potentially act through various signaling pathways to modulate the expression or activity of Angptl5 indirectly. The peroxisome proliferator-activated receptor (PPAR) agonists, such as rosiglitazone and pioglitazone, activate nuclear receptors that play a significant role in lipid metabolism and adipogenesis and can also influence the expression of proteins involved in angiogenesis. Fenofibrate and bezafibrate, as PPARα and pan-agonists, respectively, potentially influence lipid metabolism pathways, which could subsequently affect Angptl5, given the protein's association with lipid metabolism and angiogenesis.
Compounds like LY294002 and rapamycin target key kinases in the PI3K/Akt/mTOR pathway, which is crucial for cell growth, proliferation, and survival, as well as angiogenesis, a biological process in which Angptl5 is potentially involved. Modulation of this pathway can lead to altered expression of angiogenic factors. Similarly, activation of AMPK by AICAR or its precursor can influence energy homeostasis and metabolic signaling pathways, which could lead to changes in Angptl5 activity. Nicotinamide, a precursor of NAD+, and resveratrol, an activator of SIRT1, can influence metabolic and stress response pathways, which might indirectly affect Angptl5 expression or activity. Quercetin and epigallocatechin gallate (EGCG) have been shown to modulate various cellular signaling pathways, including those related to angiogenesis and metabolism, and thus may also impact Angptl5 expression indirectly.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
As a PPARγ agonist, rosiglitazone can activate the transcription of genes involved in adipogenesis, some of which might include factors that regulate angiogenesis and could upregulate Angptl5 as part of the angiogenic process. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
Pioglitazone acts on PPARγ to modulate gene expression related to glucose and lipid metabolism, potentially increasing the transcription of angiogenic modulators including Angptl5 within adipose tissue or during adipogenesis. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $41.00 | 9 | |
By activating PPARα, fenofibrate regulates fatty acid oxidation genes, which may have a secondary effect on the expression of proteins such as Angptl5, known to be involved in lipid metabolism and angiogenesis. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $31.00 $46.00 $122.00 $204.00 | 5 | |
Bezafibrate is a PPAR pan-agonist that can increase the expression of genes across all PPAR subtypes, potentially affecting the expression of Angptl5 through alterations in lipid metabolic pathways that are linked to angiogenesis. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Inhibition of PI3K by LY294002 disrupts Akt signaling, which can downregulate angiogenic pathways but may cause compensatory upregulation of other angiogenic factors, possibly including Angptl5, in an effort to maintain vascular homeostasis. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
mTOR inhibition by rapamycin disrupts angiogenesis and can lead to the altered expression of angiogenic factors. This could include a compensatory increase in Angptl5 levels as part of the cellular response to maintain angiogenic balance. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
Activation of AMPK by AICAR affects cellular energy balance and can induce the expression of various genes associated with metabolism and vascular growth, potentially including Angptl5. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide enhances NAD+ biosynthesis and can modulate sirtuin activity, leading to changes in cellular metabolism and possibly increasing the expression of angiogenic proteins such as Angptl5. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
As a SIRT1 activator, resveratrol influences pathways involved in cellular stress resistance and longevity, which could indirectly lead to increased expression of Angptl5 due to its role in vascular function and metabolism. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin's modulation of PI3K/Akt signaling can indirectly lead to altered expression of angiogenic factors, which may include Angptl5 as the cell adjusts to changes in vascular signaling. | ||||||