Angptl5 Inhibitors
Angptl5 inhibitors are a diverse set of compounds that mainly influence lipid and glucose metabolism, pathways in which Angptl5 plays a critical role. Key representatives like Atorvastatin and Simvastatin are HMG-CoA reductase inhibitors that modulate cholesterol synthesis. By influencing this essential lipid pathway, they indirectly alter Angptl5's regulatory effects on LPL, an enzyme critical for lipid utilization.
Furthermore, compounds such as Gemfibrozil target peroxisome proliferator-activated receptors (PPARs), which play pivotal roles in lipid and glucose metabolism. PPAR activation can remodel the lipid and glucose landscape in the cell, which in turn, indirectly modulates Angptl5's role in these processes. The inclusion of AMPK pathway inhibitors, like Dorsomorphin and Compound C, and the SIRT1 activator, SRT1720, reflects the importance of energy homeostasis in Angptl5's function. The interconnected nature of energy, glucose, and lipid pathways necessitates that changes in one can have ramifications on the others, indirectly influencing Angptl5's regulatory roles. The chemical class underscores the complexity of metabolic regulation and the potential points of intervention to influence proteins like Angptl5.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Atorvastatin | 134523-00-5 | sc-337542A sc-337542 | 50 mg 100 mg | $257.00 $505.00 | 9 | |
HMG-CoA reductase inhibitor affecting cholesterol synthesis. Since Angptl5 plays a role in lipid metabolism, influencing cholesterol synthesis can indirectly modulate Angptl5's regulatory effects on LPL. | ||||||
GW 3965 hydrochloride | 405911-17-3 | sc-224011 sc-224011A sc-224011B | 5 mg 25 mg 1 g | $140.00 $483.00 $3121.00 | ||
LXR agonist that modulates cholesterol metabolism. By influencing lipid transport and metabolism, Angptl5 function can be indirectly altered. | ||||||
Dorsomorphin dihydrochloride | 1219168-18-9 | sc-361173 sc-361173A | 10 mg 50 mg | $186.00 $751.00 | 28 | |
AMPK pathway inhibitor. Since AMPK plays a role in energy homeostasis and lipid metabolism, inhibiting this pathway can indirectly influence Angptl5's regulatory role. | ||||||
SRT1720 | 1001645-58-4 | sc-364624 sc-364624A | 5 mg 10 mg | $197.00 $364.00 | 13 | |
SIRT1 activator influencing cellular energy metabolism. By modulating energy homeostasis pathways, the activity of Angptl5 can be indirectly affected. | ||||||
Lipase Inhibitor, THL | 96829-58-2 | sc-203108 | 50 mg | $52.00 | 7 | |
Lipase inhibitor reducing dietary fat absorption. As Angptl5 regulates LPL activity, impacting lipase activity can indirectly modulate Angptl5's role. | ||||||
Gemfibrozil | 25812-30-0 | sc-204764 sc-204764A | 5 g 25 g | $66.00 $267.00 | 2 | |
Another PPARα agonist that affects lipid metabolism. Given Angptl5's role in lipid regulation, modulating these pathways can indirectly impact its function. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $31.00 $89.00 $135.00 $443.00 | 13 | |
Another HMG-CoA reductase inhibitor affecting cholesterol synthesis. Angptl5's regulatory effects on LPL can be indirectly modulated by influencing cholesterol pathways. | ||||||
Exendin-4 | 141758-74-9 | sc-474611 sc-474611A | 500 µg 1 mg | $146.00 $198.00 | 1 | |
GLP-1 receptor agonist affecting insulin secretion and glucose homeostasis. Alterations in glucose metabolism can have indirect implications for Angptl5's role in lipid regulation. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $292.00 $822.00 $1540.00 | 1 | |
Biguanide influencing AMPK activation and glucose metabolism. As glucose and lipid metabolisms are interconnected, modulating glucose metabolism can indirectly affect Angptl5's regulatory role. | ||||||