ANGEL2 Inhibitors
Compounds like AKT inhibitor VIII, Perifosine, Triciribine, GSK690693, MK-2206, and API-2 directly inhibit the Akt signaling pathway. Akt, also known as protein kinase B, is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription, and cell migration. By directly inhibiting Akt, these compounds can decrease the phosphorylation and activation of ANGEL2. Furthermore, Rapamycin and PI-103 can disrupt the mTOR signaling downstream of Akt. mTOR is a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, and transcription. By inhibiting mTOR, these compounds can further reduce the activation of ANGEL2. The result of these combined actions is a significant reduction in the functional activity of ANGEL2, demonstrating the effectiveness of these specific inhibitors on the PI3K/Akt signaling pathway and its associated proteins.
The specificity of these inhibitors for the PI3K/Akt pathway and the subsequent effect on ANGEL2 is not entirely coincidental. Given the pivotal role that this pathway plays in a myriad of cellular processes, it is logical that the inhibition of key components would have downstream effects on related proteins, such as ANGEL2. The specific biochemical actions of these inhibitors on PI3K, Akt, and mTOR, and the subsequent reduction in ANGEL2 activity, reflect a clear and direct modulation of the functional state of ANGEL2.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent PI3K inhibitor. PI3K is involved in many signaling pathways that can induce the phosphorylation and activation of various proteins, including ANGEL2. The inhibition of PI3K by Wortmannin can lead to a decrease in the functional activity of ANGEL2. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is another PI3K inhibitor. Its inhibition of PI3K can decrease the phosphorylation and activation of ANGEL2, thereby reducing its functional activity. | ||||||
Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 | 612847-09-3 | sc-202048 sc-202048A | 1 mg 5 mg | $204.00 $265.00 | 29 | |
AKT inhibitor VIII directly inhibits Akt, a key signaling molecule involved in the phosphorylation and activation of ANGEL2. By inhibiting Akt, the inhibitor can reduce the functional activity of ANGEL2. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid that inhibits PI3K. Its inhibition of PI3K can lead to a decrease in the phosphorylation and activation of ANGEL2, thereby reducing its functional activity. | ||||||
Perifosine | 157716-52-4 | sc-364571 sc-364571A | 5 mg 10 mg | $184.00 $321.00 | 1 | |
Perifosine is an Akt inhibitor. By inhibiting Akt, it can decrease the activation of ANGEL2, leading to a reduction in its functional activity. | ||||||
GSK 690693 | 937174-76-0 | sc-363280 sc-363280A | 10 mg 50 mg | $255.00 $1071.00 | 4 | |
GSK690693 is an Akt kinase inhibitor. Its inhibition of Akt can lead to a decrease in the phosphorylation and activation of ANGEL2, thereby reducing its functional activity. | ||||||
MK-2206 dihydrochloride | 1032350-13-2 | sc-364537 sc-364537A | 5 mg 10 mg | $178.00 $325.00 | 67 | |
MK-2206 is a highly specific Akt inhibitor. By inhibiting Akt, it can reduce the phosphorylation and activation of ANGEL2, leading to a decrease in its functional activity. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
API-2 is an Akt inhibitor. Its inhibition of Akt can lead to a decrease in the activation of ANGEL2, leading to a reduction in its functional activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor. As mTOR is a downstream effector in the PI3K/Akt pathway, its inhibition can lead to a decrease in the activation of ANGEL2. | ||||||
PI-103 | 371935-74-9 | sc-203193 sc-203193A | 1 mg 5 mg | $32.00 $128.00 | 3 | |
PI-103 is a potent inhibitor of both PI3K and mTOR. By inhibiting these molecules, it can reduce the phosphorylation and activation of ANGEL2, thereby reducing its functional activity. | ||||||