AMIGO1 Inhibitors
Chemical inhibitors of AMIGO1 can modulate its function through the strategic blockade of specific pathways and cellular processes that are essential for the protein's activity. LY294002, a PI3K inhibitor, can impede the PI3K/Akt pathway integral to cell proliferation and survival, which may be key to AMIGO1's role in cell adhesion and survival signaling. Similarly, the MEK inhibitor PD98059 disrupts the MEK/ERK pathway, possibly attenuating AMIGO1-mediated neuronal outgrowth by curtailing the pathway's role in cell cycle progression and differentiation. Inhibition by SP600125 of the JNK signaling pathway, implicated in apoptosis and neuronal functions, can lead to a reduction in AMIGO1's activity if it is part of a signaling cascade involving JNK. SB203580, a p38 MAPK inhibitor, can block the p38 signaling pathway and potentially inhibit AMIGO1 by preventing stress-induced apoptosis where AMIGO1 might play a role. U73122's inhibition of phospholipase C can disrupt inositol phosphate signaling, possibly dampening AMIGO1's modulatory action on cell adhesion.
Further influencing AMIGO1's function, the Src family kinase inhibitor PP2 can interfere with cytoskeletal dynamics that are essential for AMIGO1-mediated cell adhesion. BAPTA-AM, as a calcium chelator, can indirectly inhibit calcium-dependent pathways, potentially affecting AMIGO1's role in neurite outgrowth and cell adhesion. NF449 can inhibit G-protein-coupled receptor signaling, which, if linked to AMIGO1, would result in reduced functionality. Go6983 suppresses PKC-mediated pathways, which can affect processes such as cell adhesion and motility, potentially inhibiting AMIGO1's associated functions. Y-27632, which inhibits rho-associated protein kinases, can alter cell shape and motility pathways, potentially inhibiting AMIGO1 if its function is connected to these pathways. ML-7's inhibition of myosin light chain kinase, involved in cytoskeletal rearrangement, can affect AMIGO1's role in cell adhesion. Lastly, AG-490 targets the JAK/STAT pathway, involved in cell growth and apoptosis, and its inhibition can indirectly impact AMIGO1 if it is implicated in these processes.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor that can inhibit the PI3K/Akt pathway, which is involved in cell survival and proliferation. If AMIGO1 function is related to cell adhesion, which can influence survival signaling, LY294002's inhibition of this pathway could lead to a functional inhibition of AMIGO1 by reducing cell survival signals that may be necessary for AMIGO1's adhesive functions. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
An MEK inhibitor that disrupts the MEK/ERK pathway, which plays a role in cell cycle progression and differentiation. AMIGO1, being involved in neuronal outgrowth, may rely on this pathway for its function, so inhibition by PD98059 could lead to reduced AMIGO1-mediated neuronal outgrowth. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
A JNK inhibitor that could impede the JNK signaling pathway, which is implicated in apoptosis and neuronal functions. AMIGO1, if part of a signaling cascade involving JNK, would have reduced functional output as the JNK pathway is inhibited. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A p38 MAPK inhibitor that can block the p38 signaling pathway, involved in inflammatory responses and stress-induced apoptosis. If AMIGO1 is involved in these processes, SB203580 could indirectly inhibit its function by preventing downstream signaling. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
A Src family kinase inhibitor that could theoretically inhibit signaling pathways where Src kinases modulate cytoskeletal dynamics, which could be essential for AMIGO1-mediated cell adhesion. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
A calcium chelator that can indirectly inhibit calcium-dependent signaling pathways. As AMIGO1 is involved in cell adhesion and neurite outgrowth, processes that can be calcium-dependent, BAPTA-AM could inhibit AMIGO1's function by reducing available calcium. | ||||||
NF449 | 627034-85-9 | sc-478179 sc-478179A sc-478179B | 10 mg 25 mg 100 mg | $199.00 $460.00 $1479.00 | 1 | |
A selective and potent Gsα subunit inhibitor, which can inhibit G-protein-coupled receptor signaling. If AMIGO1's function is linked to GPCR signaling, NF449's inhibition of this pathway could indirectly inhibit AMIGO1 functionality. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
A protein kinase C inhibitor that can suppress PKC-mediated signaling pathways. Since PKC can be involved in cell adhesion and motility, Go6983 could indirectly inhibit AMIGO1 function by disrupting these pathways. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
A rho-associated protein kinase inhibitor, which could inhibit signaling pathways involved in cell shape and motility. If AMIGO1's function is connected to these pathways, then Y-27632 could indirectly inhibit its function. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
An inhibitor of myosin light chain kinase, which is involved in cytoskeletal rearrangement. AMIGO1, which may play a role in cell adhesion potentially linked to cytoskeletal dynamics, could have its function inhibited by ML-7. | ||||||