AMID Activators
AMID Activators encompass a variety of chemical compounds that indirectly promote the activity of AMID through intricate biochemical pathways associated with mitochondrial function and oxidative stress response. Resveratrol, for instance, is known for its capability to activate SIRT1, thereby enhancing the functional activity of AMID by bolstering the cellular defense against oxidative stress. Similarly, NAD+ and its precursor, Nicotinamide riboside, provide substrate enhancement to sirtuins and poly(ADP-ribose) polymerases, which indirectly support AMID activity by fostering mitochondrial health and DNA repair mechanisms. Coenzyme Q10 and Alpha-lipoic acid, both key players in mitochondrial bioenergetics and antioxidant defense, are thought to improve mitochondrial efficiency and counteract oxidative damage, thereby facilitating the role of AMID in these processes. Meanwhile, Sulforaphane and Curcumin exert their effects by activating Nrf2 and mitigating inflammation, respectively, which elevates the cellular antioxidant capacity and could, therefore, amplify the activity of AMID.
The secondary tier of AMID Activators includes compounds that influence cellular homeostasis and longevity pathways, which in turn, can impact the functionality of AMID. Spermidine, through its role in promoting autophagy, potentially clears dysfunctional mitochondria, reducing oxidative stress and indirectly increasing AMID activity. Cycloastragenol's effect on telomerase may also translate to better mitochondrial health, indirectly supporting AMID activity. Further, Pyrroloquinoline quinone (PQQ) has been associated with mitochondrial biogenesis, which could result in an enhanced number and function of mitochondria, supporting the role of AMID in these organelles. Melatonin,with its potent antioxidant effects, preserves mitochondrial integrity, thereby potentially augmenting AMID's functional activity. Lastly, Methylene blue contributes to mitochondrial respiratory efficiency and has antioxidative effects that may lead to an indirect enhancement of AMID activity by improving electron transport and decreasing oxidative stress. These compounds, through their distinct but interconnected roles in mitochondrial support and stress response, collectively contribute to the functional enhancement of AMID.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, a deacetylase involved in stress response and longevity. Since AMID is part of cellular response to oxidative stress, activation of SIRT1 can enhance the functional activity of AMID by promoting cellular resilience to stress. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
NAD+ is a substrate for sirtuins and poly(ADP-ribose) polymerases, which are involved in DNA repair and mitochondrial function. Increased NAD+ levels can indirectly enhance the activity of AMID through improved mitochondrial function and response to oxidative stress. | ||||||
Nicotinamide riboside | 1341-23-7 | sc-507345 | 10 mg | $411.00 | ||
As a precursor to NAD+, nicotinamide riboside boosts intracellular NAD+ levels, potentially enhancing AMID activity indirectly by promoting mitochondrial biogenesis and sirtuin activity. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $70.00 $180.00 | 1 | |
Coenzyme Q10 is involved in the electron transport chain and antioxidant defense. It could enhance AMID activity by improving mitochondrial efficiency and oxidative stress response. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $68.00 $120.00 $208.00 $373.00 $702.00 | 3 | |
As an antioxidant, alpha-lipoic acid can indirectly enhance AMID activity by reducing oxidative damage and maintaining mitochondrial function. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane activates Nrf2, a transcription factor that induces the expression of antioxidant proteins. This activation can indirectly enhance the activity of AMID by elevating cellular antioxidant capacity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can promote the activation of AMID through its anti-inflammatory and antioxidant properties, which may reduce oxidative stress and improve mitochondrial function. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine promotes autophagy, a process that can enhance the activity of AMID by clearing damaged mitochondria and reducing oxidative stress. | ||||||
Pyrroloquinoline quinone | 72909-34-3 | sc-210178 | 1 mg | $238.00 | ||
PQQ has been shown to support mitochondrial biogenesis, which can enhance the functional activity of AMID by increasing the number of mitochondria and potentially their efficiency. | ||||||
Melatonin | 73-31-4 | sc-207848 sc-207848A sc-207848B sc-207848C sc-207848D sc-207848E | 1 g 5 g 25 g 100 g 250 g 1 kg | $64.00 $72.00 $214.00 $683.00 $1173.00 $3504.00 | 16 | |
Melatonin has antioxidant properties and can protect mitochondria from oxidative damage, potentially enhancing AMID activity by preserving mitochondrial function. | ||||||