ALS2CR4 Inhibitors

Transmembrane Protein 237, also known as TMEM237, is a human gene that encodes a protein located in the cell membrane. TMEM237 is associated with cilia, which are slender, hair-like structures found on the surface of many cell types. Cilia have diverse functions, including cell motility, sensory perception, and signaling, and their proper function is essential for various physiological processes.TMEM237 is specifically associated with primary cilia, which are non-motile cilia found on the surface of most mammalian cells. Primary cilia play critical roles in signaling pathways and sensing extracellular signals, including those involved in development and tissue homeostasis.

Mutations in the TMEM237 gene have been linked to ciliopathies, which are a group of genetic disorders characterized by abnormal ciliary function. These disorders can affect various organ systems, leading to a wide range of manifestations. For example, mutations in TMEM237 can result in ciliopathies with features such as kidney cysts (polycystic kidney disease), retinal degeneration, and intellectual disabilities.Research on TMEM237 is ongoing, as scientists seek to understand the specific roles it plays within cilia and how mutations in this gene contribute to the development of ciliopathies. Understanding TMEM237's functions can provide insights into the molecular mechanisms underlying these disorders and may lead to potential strategies in the future.