ALS2CR4 Antibody (G-8): sc-514651
- ALS2CR4 Antibody (G-8) is a mouse monoclonal IgG1 κ ALS2CR4 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 205-226 within an internal region of ALS2CR4 of human origin
- ALS2CR4 Antibody (G-8) is recommended for detection of ALS2CR4 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-ALS2CR4 Antibody (G-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for ALS2CR4 Antibody (G-8) for WB applications. These reagents are now offered in bundles with ALS2CR4 Antibody (G-8) (see ordering information below).
QUICK LINKS
ALS2CR4 Antibody (G-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects ALS2CR4 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ALS2CR4 (G-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ALS2CR4, also known as amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 4, is a 432 amino acid multi-pass membrane protein that plays a crucial role in the retina, where ALS2CR4 is highly enriched and localized to photoreceptor outer segments, the ciliary complex, and the postsynaptic outer plexiform layer. This localization suggests ALS2CR4 involvement in the maintenance and function of photoreceptors, which are essential for vision. Mutations in the ALS2 gene, which encodes the Alsin protein that acts as a guanine nucleotide exchange factor for Rab 5, have been linked to several juvenile recessive motor neuron diseases, including juvenile primary lateral sclerosis and infantile onset ascending hereditary spastic paralysis. ALS2CR4 interaction with the endocytic pathway and potential role in membrane transport events highlight ALS2CR4 importance in cellular processes that are critical for neuronal health and function.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ALS2CR4 Antibody (G-8) References:
- The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis. | Yang, Y., et al. 2001. Nat Genet. 29: 160-5. PMID: 11586297
- Alsin is a Rab5 and Rac1 guanine nucleotide exchange factor. | Topp, JD., et al. 2004. J Biol Chem. 279: 24612-23. PMID: 15033976
- Cross-species characterization of the ALS2 gene and analysis of its pattern of expression in development and adulthood. | Devon, RS., et al. 2005. Neurobiol Dis. 18: 243-57. PMID: 15686953
- The first ALS2 missense mutation associated with JPLS reveals new aspects of alsin biological function. | Panzeri, C., et al. 2006. Brain. 129: 1710-9. PMID: 16670179
- Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities. | Devon, RS., et al. 2006. Proc Natl Acad Sci U S A. 103: 9595-600. PMID: 16769894
- Alsin/Rac1 signaling controls survival and growth of spinal motoneurons. | Jacquier, A., et al. 2006. Ann Neurol. 60: 105-17. PMID: 16802292
- Anti-ALS activity of alsin, the product of the ALS2 gene, and activity-dependent neurotrophic factor. | Matsuoka, M. and Nishimoto, I. 2005. Neurodegener Dis. 2: 135-8. PMID: 16909018
- A genome-wide association study of sporadic ALS in a homogenous Irish population. | Cronin, S., et al. 2008. Hum Mol Genet. 17: 768-74. PMID: 18057069
- Deciphering the structure and function of Als2cr4 in the mouse retina. | Zuniga, FI. and Craft, CM. 2010. Invest Ophthalmol Vis Sci. 51: 4407-15. PMID: 20375344
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ALS2CR4 Antibody (G-8) | sc-514651 | 200 µg/ml | $316.00 | |||
ALS2CR4 Antibody (G-8): m-IgG Fc BP-HRP Bundle | sc-527927 | 200 µg Ab; 10 µg BP | $354.00 | |||
ALS2CR4 Antibody (G-8): m-IgG1 BP-HRP Bundle | sc-533300 | 200 µg Ab; 20 µg BP | $354.00 | |||
ALS2CR4 Antibody (G-8) AC | sc-514651 AC | 500 µg/ml, 25% agarose | $416.00 | |||
ALS2CR4 Antibody (G-8) HRP | sc-514651 HRP | 200 µg/ml | $316.00 | |||
ALS2CR4 Antibody (G-8) FITC | sc-514651 FITC | 200 µg/ml | $330.00 | |||
ALS2CR4 Antibody (G-8) PE | sc-514651 PE | 200 µg/ml | $343.00 | |||
ALS2CR4 Antibody (G-8) Alexa Fluor® 488 | sc-514651 AF488 | 200 µg/ml | $357.00 | |||
ALS2CR4 Antibody (G-8) Alexa Fluor® 546 | sc-514651 AF546 | 200 µg/ml | $357.00 | |||
ALS2CR4 Antibody (G-8) Alexa Fluor® 594 | sc-514651 AF594 | 200 µg/ml | $357.00 | |||
ALS2CR4 Antibody (G-8) Alexa Fluor® 647 | sc-514651 AF647 | 200 µg/ml | $357.00 | |||
ALS2CR4 Antibody (G-8) Alexa Fluor® 680 | sc-514651 AF680 | 200 µg/ml | $357.00 | |||
ALS2CR4 Antibody (G-8) Alexa Fluor® 790 | sc-514651 AF790 | 200 µg/ml | $357.00 | |||
ALS2CR4 (G-8) Neutralizing Peptide | sc-514651 P | 100 µg/0.5 ml | $68.00 |