α-protein kinase 1 Activators
α-protein kinase 1 Activators are a diverse group of compounds that enhance the kinase's functional activity through various cellular mechanisms. Molecules such as Adenosine triphosphate (ATP) and Magnesium chloride (MgCl2) are direct activators; ATP provides the necessary phosphate for enzymatic activity, while MgCl2 serves as a cofactor stabilizing the ATP structure during the catalytic process. Sodium orthovanadate contributes indirectly by inhibiting phosphatases, thereby sustaining the kinase's phosphorylation effects. Similarly, Forskolin and Dibutyryl cAMP, by raising cAMP levels, and 3-Isobutyl-1-methylxanthine, by preventing cAMP degradation, activate Protein Kinase A (PKA), which may subsequently phosphorylate α-protein kinase 1 substrates or regulatory proteins. Ionomycin indirectly promotes activation by increasing intracellular calcium, which can affect calcium-dependent modulators of the kinase.
Further indirect activation of α-protein kinase 1 is achieved through the inhibition of protein phosphatases by Okadaic acid and Calyculin A, which prevents the dephosphorylation of the kinase's substrates. Anisomycin acts as astress kinase activator and could trigger a signaling cascade involving α-protein kinase 1, enhancing its activity. Phorbol 12-myristate 13-acetate (PMA) and Lysophosphatidic acid (LPA) both serve as indirect activators through their interactions with other kinases and G-protein-coupled receptors, respectively; PMA activates Protein Kinase C (PKC), which may influence α-protein kinase 1 regulatory pathways, while LPA initiates a signaling cascade that could culminate in α-protein kinase 1 activation. These compounds, by targeting specific cellular processes and signaling pathways, are capable of enhancing the activity of α-protein kinase 1, ensuring its role in phosphorylating target substrates is effectively carried out.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Magnesium chloride | 7786-30-3 | sc-255260C sc-255260B sc-255260 sc-255260A | 10 g 25 g 100 g 500 g | $27.00 $34.00 $47.00 $123.00 | 2 | |
Required as a cofactor for the enzymatic activity of α-protein kinase 1. Magnesium ions stabilize the structure of ATP and the phosphoryl group transfer to the substrate. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
Acts as a phosphatase inhibitor, indirectly enhancing the phosphorylation effect of α-protein kinase 1 by preventing dephosphorylation of its substrates, leading to sustained activation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Elevates cAMP levels in cells, which can activate PKA. Activated PKA may phosphorylate and regulate proteins that interact with or modulate α-protein kinase 1 function, indirectly enhancing its activity. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
A cAMP analog that is resistant to degradation and acts similarly to Forskolin by activating PKA, which could phosphorylate substrates of α-protein kinase 1 thereby indirectly increasing its activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
A calcium ionophore that increases intracellular calcium concentration, potentially modulating calcium-dependent proteins that interact with α-protein kinase 1, indirectly leading to its activation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
A phosphodiesterase inhibitor that prevents cAMP degradation, leading to PKA activation. This PKA activity might then enhance the phosphorylation status of α-protein kinase 1 substrates or regulatory proteins. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
A potent inhibitor of protein phosphatases 1 and 2A, which could prevent the dephosphorylation of substrates of α-protein kinase 1, indirectly sustaining its activity. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000C | 10 µg 100 µg 1 mg | $160.00 $750.00 $3000.00 | 59 | |
Similar to Okadaic acid, it inhibits certain protein phosphatases leading to increased phosphorylation levels of proteins, which might enhance the activity of α-protein kinase 1 by preventing substrate dephosphorylation. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
An activator of stress-activated protein kinases, which could lead to the activation of a signaling cascade that includes α-protein kinase 1, possibly enhancing its activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
A diacylglycerol analog that activates protein kinase C (PKC) which may phosphorylate proteins that regulate α-protein kinase 1 activity, thus indirectly enhancing its function. | ||||||