Alox12e Activators
ALOX12E Activators are a specialized set of chemical compounds that indirectly augment the enzymatic activity of ALOX12E by modulating the availability of its substrates or by influencing competing pathways. These activators, such as AA861 and Zileuton, function primarily by inhibiting the 5-lipoxygenase enzyme, thereby increasing the pool of arachidonic acid available for ALOX12E to convert into 12(S)-HETE. Similarly, MK886 and NDGA also enhance the action of ALOX12E by limiting the activity of other lipoxygenases, effectively redirecting substrate flow towards ALOX12E. Compounds such as Esculetin and Baicalein, which are known to inhibit 12-lipoxygenase, could potentially enhance ALOX12E activity by minimizing the metabolism of shared substrates, allowing more fatty acids to be available for ALOX12E's catalysis.
Furthermore, natural compounds like Oleocanthal, found in olive oil, and dietary polyphenols such as Caffeic acid, Curcumin, and Quercetin, are implicated in lipoxygenase inhibition, which could subsequently enhance ALOX12E activity by freeing up more substrates. Maslinic acid and the various catechins present in green tea function in a similar capacity, diminishing the activity of competing lipoxygenase enzymes and thus indirectly enhancing ALOX12E's role in metabolizing arachidonic acid. Collectively, these activators work by creating a more favorable biochemical environment for ALOX12E to perform its function, ensuring that the substrates are more readily available for conversion by this specific lipoxygenase, thereby enhancing its catalytic activity without directly increasing its expression or altering its intrinsic activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fostriecin | 87860-39-7 | sc-202160 | 50 µg | $260.00 | 9 | |
AA861 is a 5-lipoxygenase inhibitor. By inhibiting 5-lipoxygenase, AA861 can increase substrate availability for ALOX12E, allowing for enhanced conversion of arachidonic acid into 12(S)-HETE. | ||||||
Zileuton | 111406-87-2 | sc-204417 sc-204417A sc-204417B sc-204417C | 10 mg 50 mg 1 g 75 g | $82.00 $301.00 $362.00 $1229.00 | 8 | |
Zileuton is also a selective 5-lipoxygenase inhibitor. It can indirectly enhance ALOX12E activity by reducing competition for arachidonic acid, thus potentially increasing the enzyme's substrate availability. | ||||||
MK-886 sodium salt | 118427-55-7 | sc-200608B sc-200608 sc-200608A | 1 mg 5 mg 25 mg | $46.00 $93.00 $371.00 | 3 | |
MK886 is a leukotriene inhibitor that prevents the binding of 5-lipoxygenase activating protein (FLAP) to 5-lipoxygenase. This action may redirect arachidonic acid metabolism towards ALOX12E, enhancing its activity. | ||||||
NDGA (Nordihydroguaiaretic acid) | 500-38-9 | sc-200487 sc-200487A sc-200487B | 1 g 5 g 25 g | $107.00 $376.00 $2147.00 | 3 | |
Nordihydroguaiaretic acid (NDGA) is a lipoxygenase inhibitor. By inhibiting other lipoxygenases, NDGA may shunt arachidonic acid towards ALOX12E, facilitating its enzymatic activity. | ||||||
Esculetin | 305-01-1 | sc-200486 sc-200486A | 1 g 5 g | $43.00 $208.00 | 7 | |
Esculetin is a known inhibitor of 12-lipoxygenase, but by competing with ALOX12E's similar substrates, it could increase the availability of certain fatty acids that ALOX12E may act upon, enhancing its activity indirectly. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $31.00 $41.00 $159.00 $286.00 | 12 | |
Baicalein is an inhibitor of 12-lipoxygenase. It can enhance ALOX12E activity by reducing the metabolism of common arachidonic acid substrates by other lipoxygenases, potentially increasing the bioavailability for ALOX12E. | ||||||
Caffeic Acid | 331-39-5 | sc-200499 sc-200499A | 1 g 5 g | $31.00 $61.00 | 1 | |
Caffeic acid is a non-selective inhibitor of lipoxygenases. By reducing overall lipoxygenase activity, caffeic acid could theoretically increase the availability of ALOX12E substrates, thus enhancing its function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is a compound from turmeric that inhibits lipoxygenase activity. This could lead to enhanced ALOX12E activity by increasing available substrate levels. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid that inhibits lipoxygenase enzymes. By doing so, it could indirectly enhance the activity of ALOX12E by increasing substrate availability. | ||||||
Maslinic Acid | 4373-41-5 | sc-221873 sc-221873A | 1 mg 5 mg | $62.00 $200.00 | 2 | |
Maslinic acid is a pentacyclic triterpene that exhibits lipoxygenase inhibition. This can lead to an indirect enhancement of ALOX12E activity by increasing the pool of arachidonic acid available for conversion. | ||||||